The coexistence of pyoderma gangrenosum (PG) and chronic renal comorbidities has been reported anecdotally. We aimed to assess the bidirectional association between PG and the following chronic renal comorbidities: chronic renal failure (CRF), dialysis, kidney transplantation (KT), and other kidney diseases (OKD). That is to evaluate (i) the risk of the aforementioned diseases among patients with PG (ii) and the odds of PG after a diagnosis of renal comorbidities. A population-based retrospective cohort study was conducted comparing PG patients (n=302) with age-, sex-, and ethnicity-matched control subjects (n=1497) with regard to incident cases of renal comorbidities. A case-control design was additionally adopted to estimate the odds of PG in those with a preexisting history of renal comorbidities. Adjusted hazard ratios (HRs) and adjusted odds ratios (ORs) were estimated by Cox regression and logistic regression, respectively. Patients with PG demonstrated an increased risk of CRF (adjusted HR, 3.68; 95% CI, 2.72–5.97), dialysis (adjusted HR, 27.79; 95% CI, 3.24–238.14), and OKD (adjusted HR, 2.71; 95% CI, 1.55–4.74). In addition, the odds of PG were increased after the diagnosis of CRF (adjusted OR, 2.34; 95% CI, 1.33–4.11), KT (adjusted OR, 5.03; 95% CI, 1.01–25.12), and OKD (adjusted OR, 1.69; 95% CI, 1.04–2.74). Patients with a dual diagnosis of PG and renal diseases presented with PG at an older age and had a higher prevalence of comorbid conditions. In conclusion, a bidirectional association exists between PG and chronic renal conditions. Awareness of this comorbidity may be of benefit for physicians managing patients with PG.

据报道，坏疽性脓皮病（PG）与慢性肾脏合并症并存。我们的目的是评估 PG 与以下慢性肾脏合并症之间的双向关联：慢性肾衰竭 (CRF)、透析、肾移植 (KT) 和其他肾脏疾病 (OKD)。即评估 (i) PG 患者患上述疾病的风险 (ii) 以及诊断出肾脏合并症后发生 PG 的几率。进行了一项基于人群的回顾性队列研究，将 PG 患者 ( n = 302) 与年龄、性别和种族匹配的对照受试者 ( n = 1497) 的肾脏合并症事件进行比较。另外还采用病例对照设计来估计有肾脏合并症病史的患者发生 PG 的几率。分别通过 Cox 回归和逻辑回归估计调整后的风险比 (HR) 和调整后的比值比 (OR)。PG 患者发生 CRF（调整后 HR，3.68；95% CI，2.72-5.97）、透析（调整后 HR，27.79；95% CI，3.24-238.14）和 OKD（调整后 HR，2.71；95%）风险增加CI，1.55–4.74）。此外，诊断CRF（调整后的OR，2.34；95% CI，1.33-4.11）、KT（调整后的OR，5.03；95% CI，1.01-25.12）和OKD（调整后的OR，1.01-25.12）后，PG的几率增加。 ，1.69；95% CI，1.04–2.74）。具有 PG 和肾脏疾病双重诊断的患者出现 PG 的年龄较大，并且合并症的患病率较高。总之，PG 和慢性肾脏病之间存在双向关联。对这种合并症的认识可能对治疗 PG 患者的医生有益。