Development of the ovary or testis is required to establish reproductive competence. Gonad development relies on key cell fate decisions that occur early in embryonic development and are actively maintained. During gonad development, both germ cells and somatic cells proliferate extensively, a process facilitated by cell cycle regulation. This review focuses on the Cip/Kip family of cyclin-dependent kinase inhibitors (CKIs) in mouse gonad development. We particularly highlight recent single-cell RNA sequencing studies that show the heterogeneity of cyclin-dependent kinase inhibitors. This diversity highlights new roles for cell cycle inhibitors in controlling and maintaining female fertility.

中文翻译：

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建立和维持生育能力：细胞周期停滞的重要性

卵巢或睾丸的发育是建立生殖能力所必需的。性腺发育依赖于胚胎发育早期发生并得到积极维持的关键细胞命运决定。在性腺发育过程中，生殖细胞和体细胞都广泛增殖，细胞周期调节促进了这一过程。这篇综述的重点是 Cip/Kip 家族的细胞周期蛋白依赖性激酶抑制剂 (CKI) 在小鼠性腺发育中的作用。我们特别强调了最近的单细胞 RNA 测序研究，这些研究显示了细胞周期蛋白依赖性激酶抑制剂的异质性。这种多样性突出了细胞周期抑制剂在控制和维持女性生育能力方面的新作用。