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Progress in [18F]Fluorination by Using Aryliodonium(III) Compounds and Application for PET Tracer Syntheses
Mini-Reviews in Organic Chemistry ( IF 1.9 ) Pub Date : 2021-02-28 , DOI: 10.2174/1570193x17999200629155733
Kotaro Kikushima 1 , Ravi Kumar 2 , Toshifumi Dohi 1
Affiliation  

[18F]-labeled drugs and radioligands are most frequently used in positron-emission tomography (PET) radiopharmaceuticals for both clinical and preclinical research. Various methods for the introduction of [18F]fluorine into complex molecules through fluorination reactions have been reported. Herein, recent advances in [18F]-fluorination utilizing aryliodonium(III) compounds are highlighted.



中文翻译:

阿魏烯鎓(III)化合物在[ 18 F]氟化中的进展及其在PET示踪剂合成中的应用

[ 18 F]标记的药物和放射性配体最常用于正电子发射断层扫描(PET)放射性药物中,用于临床和临床前研究。已经报道了通过氟化反应将[ 18 F]氟引入复杂分子的各种方法。本文中,突出了利用芳基碘鎓(III)化合物在[ 18 F]氟化中的最新进展。

更新日期:2021-04-22
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