This review reports various synthetic routes of pyrazolone/ pyrazolinone derivatives via the addition of cycloaddition, condensation, cyclocondensation, modification, alkylation, as well as formylation, regioselective, and ring-opening reactions under reflux, microwave irradiation, and/ or ultrasonication conditions. It also presents critical chemical behaviors towards nucleophilic and electrophilic reagents. The chemical reactivities of pyrazolone/ pyrazolinone derivatives involve alkylation, acylation, condensation, catalyzed diazo coupling, oxidation, heteroarylation, phosphorylation, stereoselective alkenylation, enantioselective alkylation, addition, and complexation reactions. The review also summarizes the significant biological activity of pyrazolone/ pyrazolinone derivatives as antibacterial, antifungal, anti-inflammatory, anticancer, antitumor, anthelmintic, analgesic, as well as antioxidant, anthelmintic, antibiofilm, and anti-HIV. Moreover, some pyrazolone/ pyrazolinone derivatives used to remove various metal or soft metal ions from the wastewater. Besides, they exhibited stable complexes with some metals, for example, Ag (I), Cu (I), Cu (II), Hg (II), Pb (II), Sn (II), and Sb (V) as new materials, catalysis, and precursors for CVD in the microelectronic industry and as potential antitumoral.

该综述报道了在回流，微波辐射和/或超声条件下，通过添加环加成，缩合，环缩合，修饰，烷基化以及甲酰化，区域选择性和开环反应，吡唑啉酮/吡唑啉酮衍生物的各种合成路线。它还显示了对亲核试剂和亲电试剂的关键化学行为。吡唑啉酮/吡唑啉酮衍生物的化学反应性涉及烷基化，酰化，缩合，催化的重氮偶合，氧化，杂芳基化，磷酸化，立体选择性烯基化，对映选择性烷基化，加成和络合反应。审查还总结了吡唑啉酮/吡唑啉酮衍生物具有显着的生物学活性，具有抗菌，抗真菌，抗炎，抗癌，抗肿瘤，驱虫药，止痛药，以及抗氧化剂，驱虫药，抗生物膜和抗HIV。此外，一些吡唑啉酮/吡唑啉酮衍生物用于从废水中去除各种金属或软金属离子。此外，它们还表现出与某些金属的稳定配合物，例如新的Ag（I），Cu（I），Cu（II），Hg（II），Pb（II），Sn（II）和Sb（V）微电子工业中CVD的材料，催化作用和前体，以及潜在的抗肿瘤作用。