Various neurodegenerative disorders have various molecular origins but some common molecular mechanisms. In the current scenario, there are very few treatment regimens present for advanced neurodegenerative diseases. In this context, there is an urgent need for alternate options in the form of natural compounds with an ameliorating effect on patients. There have been individual scattered experiments trying to identify potential values of various intracellular metabolites. Purines and Pyrimidines, which are vital molecules governing various aspects of cellular biochemical reactions, have been long sought as crucial candidates for the same, but there are still many questions that go unanswered. Some critical functions of these molecules associated with neuromodulation activities have been identified. They are also known to play a role in foetal neurodevelopment, but there is a lacuna in understanding their mechanisms. In this review, we have tried to assemble and identify the importance of purines and pyrimidines, connecting them with the prevalence of neurodegenerative diseases. The leading cause of this class of diseases is protein misfolding and the formation of amyloids. A direct correlation between loss of balance in cellular homeostasis and amyloidosis is yet an unexplored area. This review aims at bringing the current literature available under one umbrella serving as a foundation for further extensive research in this field of drug development in neurodegenerative diseases.

多种神经退行性疾病具有多种分子起源，但具有一些常见的分子机制。在当前情况下，针对晚期神经退行性疾病的治疗方案很少。在这种情况下，迫切需要天然化合物形式的替代选择，其对患者有改善作用。有个别分散的实验试图确定各种细胞内代谢物的潜在价值。嘌呤和嘧啶是控制细胞生化反应各个方面的重要分子，人们长期以来一直在寻求嘌呤和嘧啶作为它们的重要候选者，但仍有许多问题尚未得到解答。已经确定了这些分子与神经调节活性有关的一些关键功能。还已知它们在胎儿神经发育中起作用，但是在理解其机制方面存在缺陷。在这篇综述中，我们试图组装和鉴定嘌呤和嘧啶的重要性，并将它们与神经退行性疾病的流行联系起来。这类疾病的主要原因是蛋白质错误折叠和淀粉样蛋白的形成。细胞稳态平衡的丧失与淀粉样变性之间的直接关联尚待开发。这篇综述的目的是将现有文献放在一个保护伞下，为在神经退行性疾病药物开发领域的进一步广泛研究奠定基础。我们尝试组装并确定嘌呤和嘧啶的重要性，并将它们与神经退行性疾病的流行联系起来。这类疾病的主要原因是蛋白质错误折叠和淀粉样蛋白的形成。细胞稳态平衡的丧失与淀粉样变性之间的直接关联尚待开发。这篇综述的目的是将现有文献放在一个保护伞下，为在神经退行性疾病药物开发领域的进一步广泛研究奠定基础。我们尝试组装并确定嘌呤和嘧啶的重要性，并将它们与神经退行性疾病的流行联系起来。这类疾病的主要原因是蛋白质错误折叠和淀粉样蛋白的形成。细胞稳态平衡的丧失与淀粉样变性之间的直接关联尚待开发。这篇综述旨在将当前的文献放在一个保护伞下，为在神经退行性疾病药物开发领域的进一步广泛研究奠定基础。