Objective:

This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort.

Methods:

From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI.

Results:

The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84-0.97) in the dementia group. According to the subgroup analysis, the adjusted OR for HZI was 0.91 (95% confidence interval [CI] = 0.83 -1.00) in the < 80 years old group, 0.88 (95% CI = 0.78 -1.00) in the ≥ 80 years old group, 0.77 (95% CI = 0.66-0.89) in men and 0.96 (95% CI = 0.88 -1.05) in women.

Conclusions:

We concluded that HZI does not increase the risk of neurodegenerative dementia in individuals of any age or of either sex.

中文翻译：

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带状疱疹不会增加神经退行性痴呆的风险：病例对照研究

 客观的：

本研究旨在利用全国样本队列评估神经退行性痴呆与带状疱疹感染 (HZI) 之间的关联。

 方法：

从韩国国民健康保险公团进行的全国队列研究中，我们提取了神经退行性痴呆患者和 1:4 匹配的对照参与者的数据，并搜索了患者的 HZI 病史。

 结果：

痴呆组中 HZI 的调整后比值比 (OR) 为 0.90 (95% CI = 0.84-0.97)。根据亚组分析，< 80 岁组中 HZI 的调整 OR 为 0.91（95% 置信区间 [CI] = 0.83 -1.00），≥ 80 岁组中为 0.88（95% CI = 0.78 -1.00）老年组，男性为 0.77 (95% CI = 0.66-0.89)，女性为 0.96 (95% CI = 0.88 -1.05)。

 结论：

我们的结论是，HZI 不会增加任何年龄或性别的个体患神经退行性痴呆的风险。