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Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study
American Journal of Alzheimer's Disease and other Dementias ( IF 2.7 ) Pub Date : 2021-04-22 , DOI: 10.1177/15333175211006504
Hyo Geun Choi 1, 2 , Bum Jung Park 1 , Jae Sung Lim 3 , Song Yong Sim 4 , Yoon Jung Jung 5 , Suk Woo Lee 5
Affiliation  

Objective:

This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort.

Methods:

From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI.

Results:

The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84-0.97) in the dementia group. According to the subgroup analysis, the adjusted OR for HZI was 0.91 (95% confidence interval [CI] = 0.83 -1.00) in the < 80 years old group, 0.88 (95% CI = 0.78 -1.00) in the ≥ 80 years old group, 0.77 (95% CI = 0.66-0.89) in men and 0.96 (95% CI = 0.88 -1.05) in women.

Conclusions:

We concluded that HZI does not increase the risk of neurodegenerative dementia in individuals of any age or of either sex.



中文翻译:


带状疱疹不会增加神经退行性痴呆的风险:病例对照研究


 客观的:


本研究旨在利用全国样本队列评估神经退行性痴呆与带状疱疹感染 (HZI) 之间的关联。

 方法:


从韩国国民健康保险公团进行的全国队列研究中,我们提取了神经退行性痴呆患者和 1:4 匹配的对照参与者的数据,并搜索了患者的 HZI 病史。

 结果:


痴呆组中 HZI 的调整后比值比 (OR) 为 0.90 (95% CI = 0.84-0.97)。根据亚组分析,< 80 岁组中 HZI 的调整 OR 为 0.91(95% 置信区间 [CI] = 0.83 -1.00),≥ 80 岁组中为 0.88(95% CI = 0.78 -1.00)老年组,男性为 0.77 (95% CI = 0.66-0.89),女性为 0.96 (95% CI = 0.88 -1.05)。

 结论:


我们的结论是,HZI 不会增加任何年龄或性别的个体患神经退行性痴呆的风险。

更新日期:2021-04-22
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