Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2021-04-22 , DOI: 10.1007/s13659-021-00303-2 Marsya Yonna Nurrachma 1 , Deamon Sakaraga 1 , Ahmad Yogi Nugraha 1 , Siti Irma Rahmawati 1 , Asep Bayu 1 , Linda Sukmarini 1 , Akhirta Atikana 1 , Anggia Prasetyoputri 1 , Fauzia Izzati 1 , Mega Ferdina Warsito 1 , Masteria Yunovilsa Putra 1
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Abstract
Soft corals are well-known as excellent sources of marine-derived natural products. Among them, members of the genera Sarcophyton, Sinularia, and Lobophytum are especially attractive targets for marine natural product research. In this review, we reported the marine-derived natural products called cembranoids isolated from soft corals, including the genera Sarcophyton, Sinularia, and Lobophytum. Here, we reviewed 72 reports published between 2016 and 2020, comprising 360 compounds, of which 260 are new compounds and 100 are previously known compounds with newly recognized activities. The novelty of the organic molecules and their relevant biological activities, delivered by the year of publication, are presented. Among the genera presented in this report, Sarcophyton spp. produce the most cembranoid diterpenes; thus, they are considered as the most important soft corals for marine natural product research. Cembranoids display diverse biological activities, including anti-cancer, anti-bacterial, and anti-inflammatory. As cembranoids have been credited with a broad range of biological activities, they present a huge potential for the development of various drugs with potential health and ecological benefits.
Graphic Abstract
中文翻译：
软珊瑚的西松烷类化合物：最新更新及其生物活性
摘要
软珊瑚是众所周知的海洋天然产品的极好来源。其中， Sarcophyton、Sinularia和Lobophytum属的成员是海洋天然产物研究特别有吸引力的目标。在这篇综述中，我们报道了从软珊瑚中分离出的海洋衍生天然产物，称为西松烷类化合物，包括肉藻属、Sinularia属和Lobophytum 属。在这里，我们回顾了 2016 年至 2020 年间发表的 72 份报告，包括 360 种化合物，其中 260 种是新化合物，100 种是先前已知的具有新认识的活性的化合物。介绍了按出版年份提供的有机分子的新颖性及其相关生物活性。在本报告中介绍的属中，Sarcophyton spp。产生最多的西松烷二萜；因此，它们被认为是海洋天然产物研究最重要的软珊瑚。西松烷内酯具有多种生物活性，包括抗癌、抗菌和抗炎。由于西松烷类化合物被认为具有广泛的生物活性，因此它们在开发具有潜在健康和生态效益的各种药物方面具有巨大的潜力。
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