Despite significant signs of progress in cancer treatment over the past decade, either cancer prevalence or mortality continuously grow worldwide. Current anti-cancer agents show insignificant effectiveness, followed by serious side effects. It is important to find new, highly efficient pharmacological agents to increase cancer patients’ clinical outcomes. Curcumin, a polyphenolic compound, has gained growing attention because of its anti-cancer properties. Curcumin can hinder the development, migration, and metastasis of cancer cells. The anti-cancer effects of curcumin are principally attributed to the regulation of several cellular signaling pathways, including MAPK/PI3K/Akt, Wnt/β-catenin, JAK/STAT, and NF-ĸB signaling pathways. Furthermore, curcumin can affect the expression and function of tumor-suppressive and oncogenic long non-coding RNAs (lncRNAs). In this study, we briefly reviewed the modulatory effect of curcumin on dysregulated tumor-supportive and tumor-suppressive lncRNAs in several cancers. It is hoped that a better understanding of curcumin’s anti-cancer properties would pave the way for the development of a therapeutic approach in cancer.

尽管在过去十年中癌症治疗取得了重大进展，但癌症患病率或死亡率在全球范围内持续增长。目前的抗癌药物效果并不明显，其次是严重的副作用。寻找新的、高效的药物制剂以提高癌症患者的临床结果非常重要。姜黄素是一种多酚化合物，因其抗癌特性而受到越来越多的关注。姜黄素可以阻碍癌细胞的发育、迁移和转移。姜黄素的抗癌作用主要归因于几种细胞信号通路的调节，包括 MAPK/PI3K/Akt、Wnt/β-catenin、JAK/STAT 和 NF-ĸB 信号通路。此外，姜黄素可以影响抑制肿瘤和致癌的长链非编码 RNA (lncRNA) 的表达和功能。在这项研究中，我们简要回顾了姜黄素对几种癌症中失调的肿瘤支持和肿瘤抑制 lncRNA 的调节作用。希望更好地了解姜黄素的抗癌特性将为开发癌症治疗方法铺平道路。