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Synovial Sarcoma Oncogenesis Revealed by Single-Cell Profiling
Trends in Cancer ( IF 14.3 ) Pub Date : 2021-04-21 , DOI: 10.1016/j.trecan.2021.03.002
Alvin Qiu 1 , Torsten O Nielsen 1
Affiliation  

Synovial sarcoma is a soft tissue malignancy driven by the SS18–SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18–SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation.



中文翻译:

单细胞分析揭示滑膜肉瘤的发生

滑膜肉瘤是一种由 SS18-SSX 融合癌蛋白驱动的软组织恶性肿瘤。在《自然医学》中,Jerby-Arnon等人提出了滑膜肉瘤的单细胞数据集,揭示了由 SS18-SSX 驱动的新型“核心致癌程序”,对基于表观遗传学、细胞周期控制和免疫增强的治疗策略有影响。

更新日期:2021-05-18
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