Synovial sarcoma is a soft tissue malignancy driven by the SS18–SSX fusion oncoprotein. In Nature Medicine, Jerby-Arnon et al. present a single-cell dataset for synovial sarcoma that reveals a novel 'core oncogenic program' driven by SS18–SSX, with implications for treatment strategies based on epigenetics, cell-cycle control, and immune augmentation.

中文翻译：

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单细胞分析揭示滑膜肉瘤的发生

滑膜肉瘤是一种由 SS18-SSX 融合癌蛋白驱动的软组织恶性肿瘤。在《自然医学》中，Jerby-Arnon等人。提出了滑膜肉瘤的单细胞数据集，揭示了由 SS18-SSX 驱动的新型“核心致癌程序”，对基于表观遗传学、细胞周期控制和免疫增强的治疗策略有影响。