High serum levels of triglycerides (Tg) and low levels of high-density lipoprotein cholesterol (HDL-C) are characteristic of the Metabolic Syndrome (MetS). We assessed the ratio of Tg to HDL-C as a way to identify MetS and insulin resistance. We also evaluated its association with severity of carotid atherosclerosis. Data were analyzed from three cohorts totaling 13,908 participants. MetS was defined according to the International Diabetes Federation criteria. Optimal cut-off for Tg/HDL-C ratio was obtained using Youden's index in receiver-operating characteristic (ROC) curve analyses. The risk of MetS and IR in those with a Tg/HDL-C ratio above the optimum cutoff was evaluated by logistic regression analysis. A Tg/HDL-C ratio above the optimal cutoff level significantly increased the odds ratio for MetS in the three cohorts (OR 6.00, 4.04, and 3.50, least in the healthy population), identified insulin resistance defined by the homeostatic model of insulin resistance (HOMA-IR) (p < 0.0001), and was strongly associated with atherosclerosis severity (p = 0.0001). Tg/HDL-C ratio identifies persons with MetS, insulin resistance, and severe atherosclerosis. It should be used more widely to identify patients at high risk. This is clinically important because insulin resistance is treatable.

中文翻译：

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甘油三酯/高密度脂蛋白胆固醇比率：代谢综合征、胰岛素抵抗和严重动脉粥样硬化的线索

高血清甘油三酯 (Tg) 水平和低水平高密度脂蛋白胆固醇 (HDL-C) 是代谢综合征 (MetS) 的特征。我们评估了 Tg 与 HDL-C 的比率，以此作为识别 MetS 和胰岛素抵抗的一种方式。我们还评估了它与颈动脉粥样硬化严重程度的关联。分析了来自三个队列的数据，共有 13,908 名参与者。MetS 是根据国际糖尿病联盟标准定义的。在接受者操作特征 (ROC) 曲线分析中使用约登指数获得 Tg/HDL-C 比率的最佳截止值。通过逻辑回归分析评估 Tg/HDL-C 比值高于最佳临界值的人发生 MetS 和 IR 的风险。高于最佳截止水平的 Tg/HDL-C 比率显着增加了三个队列中 MetS 的优势比（OR 6.00、4.04、p  < 0.0001），并且与动脉粥样硬化的严重程度密切相关（p  = 0.0001）。Tg/HDL-C 比率可识别患有 MetS、胰岛素抵抗和严重动脉粥样硬化的人。它应该被更广泛地用于识别高危患者。这在临床上很重要，因为胰岛素抵抗是可以治疗的。