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Integration of 103 Semivolatile Organic Compounds into One Multianalyte Method for Human Serum Analysis: An Innovative Approach within Exposure Assessment
Environmental Science & Technology Letters ( IF 8.9 ) Pub Date : 2021-04-21 , DOI: 10.1021/acs.estlett.1c00285 Xiu Wang 1 , Kai Huang 1 , Lingshuai Zeng 1 , Xiu Zhang 1 , Danqi Cheng 1 , Ruifang Li 1 , Yikai Zhou 1 , Tao Jing 1
Environmental Science & Technology Letters ( IF 8.9 ) Pub Date : 2021-04-21 , DOI: 10.1021/acs.estlett.1c00285 Xiu Wang 1 , Kai Huang 1 , Lingshuai Zeng 1 , Xiu Zhang 1 , Danqi Cheng 1 , Ruifang Li 1 , Yikai Zhou 1 , Tao Jing 1
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Semivolatile organic compounds (SVOCs) are frequently detected in the environment, and humans are exposed to a mixture of chemicals via multiple exposure pathways. However, there are few data on health outcomes caused by the cumulative exposure or toxicological interactions, due to the absence of simultaneous analytical methods. Herein, we present a method for simultaneous determination of 103 SVOCs, including seven phthalate esters, seven polychlorinated biphenyls, 16 polycyclic aromatic hydrocarbons, five polybromodiphenyl ethers, and 68 pesticides, in 0.5 mL of serum. The two-step extraction coupled with gas chromatography-tandem mass spectrometry was described with a single chromatographic run within 36.65 min. Methodological parameters such as recovery rates, matrix effects, and limits of detection were studied and complied with the validation guidelines. The absolute and relative recoveries ranged from 65.45% to 123.83%, and the relative standard deviations were ≤21.43%. The detection limits were <0.41 μg L–1. This method was then successfully applied to the analysis of 99 real serum samples. The developed protocol achieved a limit of quantification at a level of parts per billion for all compounds and presented benefits for the control of confounding factors, cumulative exposure, and risk assessment in population studies.
中文翻译：
将103种半挥发性有机化合物整合到一种用于人体血清分析的多分析物方法中：接触评估中的创新方法
半挥发性有机化合物（SVOC）在环境中经常被检测到，并且人类通过多种暴露途径暴露于多种化学物质中。然而，由于缺乏同步分析方法，关于累积暴露或毒理学相互作用导致健康后果的数据很少。在本文中，我们提出了一种同时测定0.5 mL血清中103种SVOC的方法，其中包括7种邻苯二甲酸酯，7种多氯代联苯，16种多环芳烃，5种多溴二苯醚和68种农药。描述了在36.65分钟内进行一次色谱分析的气相色谱-串联质谱联用的两步萃取方法。方法学参数，例如回收率，基质效应，研究了检测限和检测限，并符合验证准则。绝对和相对回收率在65.45％至123.83％之间，相对标准偏差≤21.43％。检出限<0.41μgL–1。该方法随后成功地用于分析99个真实血清样品。制定的方案对所有化合物均达到了十亿分之几的定量限，并为控制混杂因素，累积暴露和人群研究中的风险评估带来了好处。
更新日期：2021-05-11
中文翻译：
将103种半挥发性有机化合物整合到一种用于人体血清分析的多分析物方法中：接触评估中的创新方法
半挥发性有机化合物（SVOC）在环境中经常被检测到，并且人类通过多种暴露途径暴露于多种化学物质中。然而，由于缺乏同步分析方法，关于累积暴露或毒理学相互作用导致健康后果的数据很少。在本文中，我们提出了一种同时测定0.5 mL血清中103种SVOC的方法，其中包括7种邻苯二甲酸酯，7种多氯代联苯，16种多环芳烃，5种多溴二苯醚和68种农药。描述了在36.65分钟内进行一次色谱分析的气相色谱-串联质谱联用的两步萃取方法。方法学参数，例如回收率，基质效应，研究了检测限和检测限，并符合验证准则。绝对和相对回收率在65.45％至123.83％之间，相对标准偏差≤21.43％。检出限<0.41μgL–1。该方法随后成功地用于分析99个真实血清样品。制定的方案对所有化合物均达到了十亿分之几的定量限，并为控制混杂因素，累积暴露和人群研究中的风险评估带来了好处。
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