Solvent-free, continuous flow synthesis of [OMIM]Br in a microfluidic platform is reported for the first time. The microreactor comprises of a 862 µm diameter microbore tube attached to a 750 µm diameter opposed T-junction. Systematic experiments are conducted to study the effects of residence time, reaction temperature and flow velocity on product yield, space-time-yield, production rate and specific power consumption. An increase in residence time and reaction temperature is seen to increase product yield and production rate. At constant residence time, an increase in flow velocity is found to slightly increase product yield suggesting presence of mass transfer resistances at low velocities. Kinetic parameters of the alkylation reaction are determined. A pseudo first order kinetics is found to fit the experimental data better than second order kinetics. Frequency factor and activation energy for the pseudo first order reaction are found to be 3361.83 L/mol-s and 47964.76 J/mol, respectively. [OMIM]Br yield of 58.75 % can be achieved within 4.74 min residence time at 90°C. Under these conditions, the overall reaction is kinetically controlled (Ha being 0.004). Corresponding values of space-time-yield, production rate and specific power consumption are 119.15 g/min-L, 5284 g/day and 10.46 W/kg, respectively.

首次报道了在微流体平台上无溶剂连续流动合成[OMIM] Br。微型反应器包括一个直径862 µm的微孔管，该管连接到直径750 µm的相对T型结。进行了系统的实验，以研究停留时间，反应温度和流速对产物收率，时空产率，生产率和单位能耗的影响。停留时间和反应温度的增加被认为增加了产物的产率和生产率。在恒定的停留时间下，发现流速的增加会稍微增加产品的产率，这表明在低速度下存在传质阻力。确定烷基化反应的动力学参数。发现伪一阶动力学比二阶动力学更适合实验数据。拟一级反应的频率因子和活化能分别为3361.83 L / mol-s和47964.76 J / mol。[OMIM] Br在90.C的4.74分钟停留时间内可达到58.75％的溴收率。在这些条件下，整个反应是动力学控制的（Ha为0.004）。时空产率，生产率和单位能耗的相应值分别为119.15 g / min-L，5284 g / day和10.46 W / kg。整个反应是动力学控制的（Ha为0.004）。时空产率，生产率和单位能耗的相应值分别为119.15 g / min-L，5284 g / day和10.46 W / kg。整个反应是动力学控制的（Ha为0.004）。时空产率，生产率和单位能耗的相应值分别为119.15 g / min-L，5284 g / day和10.46 W / kg。