Our aim is to use neurophysiological sleep-related consolidation phenomena to identify putative pathophysiological mechanisms in CECTS linked to diffuse neurocognitive deficits. We argue that there are numerous studies on the association between seizure aspects and neurocognitive functioning but not as many on interictal variables and neurocognitive deficits. We suggest two additional foci. First, the interictal presentation in CECTS and second, neuronal oscillations involved in sleep-related consolidation processes. Existing data on mechanisms through which interictal epileptiform spikes impact upon sleep-related consolidation indicate that they have the potential to: a) perturb cross-regional coupling of neuronal oscillations, b) mimic consolidation processes, c) alter the precision of the spatiotemporal coupling of oscillations, and d) variably impact upon sleep-related consolidation performance. Sleep spindles merit systematic study in CECTS in order to clarify: a) the state of the slow oscillations with which they coordinate, b) the precision of slow oscillation-spindle coupling, and c) whether their developmental trajectories differ from those of healthy children. We subsequently review studies on the associations between IES load during NREM sleep and sleep-related consolidation performance in childhood epilepsy. We then use sleep consolidation neurophysiological processes and their interplay with IES to help clarify the diffuse neurocognitive deficits that have been empirically documented in CECTS. We claim that studying sleep-related consolidation in CECTS will help to clarify pathophysiological mechanisms towards diverse neurocognitive deficits. Future developments could include close links between the fields of epilepsy and sleep, as well as new therapeutic neurostimulation targets.

中文翻译：

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CECTS中与睡眠有关的巩固和神经认知合并症的改变

我们的目的是利用与睡眠有关的神经生理学现象来识别与弥散性神经认知功能障碍有关的CECTS的假定病理生理机制。我们认为，关于癫痫发作方面与神经认知功能之间关系的研究很多，但关于发作间期变量和神经认知缺陷的研究却不多。我们建议另外两个焦点。首先，CECTS的发作间期表现，其次，与睡眠相关的巩固过程有关的神经元振荡。现有的有关发作间期癫痫样峰影响睡眠相关巩固机制的数据表明，它们有潜力：a）扰动神经元振荡的跨区域耦合，b）模拟巩固过程，c）改变时空耦合的精度。振荡，d）对与睡眠有关的巩固表现有不同的影响。睡眠纺锤值得在CECTS中进行系统研究，以阐明：a）与其协调的慢振动的状态，b）慢振动与主轴耦合的精度，以及c）它们的发育轨迹是否与健康儿童的发育轨迹不同。我们随后回顾了有关NREM睡眠期间IES负荷与儿童癫痫中与睡眠相关的巩固表现之间的关联的研究。然后，我们使用睡眠巩固神经生理过程及其与IES的相互作用来帮助阐明在CECTS中已通过经验证明的弥散性神经认知功能障碍。我们声称，研究CECTS中与睡眠有关的巩固将有助于阐明针对各种神经认知功能障碍的病理生理机制。