Synthetic chemicals including organochlorine pesticides pose environment and health hazard due to persistent and bio-accumulation property. Majority of them are recognized as endocrine disruptors. Fungi are ubiquitous in nature and employs efficient enzymatic machinery for the biotransformation and degradation of toxic, recalcitrant pollutants. This review critically discusses the organochlorine biotransformation process mediated by fungi and highlights the role of enzymatic system responsible for biotransformation, especially distribution of dehalogenase homologs among fungal classes. It also explores the potential use of fungal derived biomaterial, mainly chitosan as an adsorbing biomaterial for pesticides and heavy metals removal. Further, prospects of employing fungus to over-come the existing bioremediation limitations are discussed. The study highlights the potential scope of utilizing fungi for initial biotransformation purposes, preceding final biodegradation by bacterial species under environmental conditions.

由于持久性和生物累积性，包括有机氯农药在内的合成化学品会对环境和健康造成危害。其中大多数被认为是内分泌干扰物。真菌在自然界中无处不在，并采用高效的酶促机制来生物转化和降解有毒、顽固的污染物。这篇综述批判性地讨论了真菌介导的有机氯生物转化过程，并强调了负责生物转化的酶系统的作用，特别是脱卤酶同源物在真菌类中的分布。它还探索了真菌衍生生物材料的潜在用途，主要是壳聚糖作为吸附生物材料，用于杀虫剂和重金属去除。此外，还讨论了使用真菌克服现有生物修复限制的前景。