In this paper, we consider a mathematical model of a tumor-immune system interaction when a periodic immunotherapy treatment is applied. We give sufficient conditions, using averaging theory, for the existence and stability of periodic solutions in such system as a function of the six parameters associated to this problem. Finally, we provide examples where our results are applied.

中文翻译：

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定期免疫疗法下肿瘤与免疫系统相互作用的定期解决方案

在本文中，我们考虑了采用定期免疫疗法治疗时肿瘤与免疫系统相互作用的数学模型。我们使用平均理论给出了充分的条件，以根据与该问题相关的六个参数来确定此类系统中周期解的存在性和稳定性。最后，我们提供了应用结果的示例。