Abstract

This paper studies the influence of lattice and shell type architecture on the mechanical properties of biodegradable polymer scaffolds (cellular matrices) designed to create structures for bone tissue engineering. Varying the topology of nodal connections makes it possible to control the relative rigidity of the metamaterial in the range from 0.004 to 0.123. It is shown to be possible to create permeable scaffolds using thermally extruded 3D printing based on polymers of different elasticities—polylactide and polyurethane. The use of “unit cells” of various types allows fabricating structures such as shells based on polylactide with a compressive strength of 1.5 to 19.7 MPa. Shells with a cubic type architecture based on polyurethane can be almost reversibly deformed at values of deformation of more than 50%. The developed approaches for obtaining polymer metamaterials and modifying their surface with calcium phosphate layer using an artificial interstitial fluid can increase the hydrophilicity of materials.

中文翻译：

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基于可生物降解复合材料的适应性超材料，用于骨组织再生

摘要

本文研究了晶格和壳型结构对可生物降解的聚合物支架（细胞基质）的力学性能的影响，这些支架被设计用于创建用于骨组织工程的结构。改变节点连接的拓扑结构可以将超材料的相对刚度控制在0.004至0.123之间。已显示有可能使用基于不同弹性的聚合物（聚丙交酯和聚氨酯）的热挤压3D打印技术来创建可渗透的脚手架。使用各种类型的“晶胞”可以制造结构，例如基于聚丙交酯的壳，其抗压强度为1.5至19.7 MPa。具有基于聚氨酯的立方型结构的壳体在变形值大于50％时几乎可以可逆地变形。