Infections caused by viruses are one of the foremost causes of morbidity and mortality in the world. Although a number of antiviral drugs are currently used for treatment of various kinds of viral infection diseases, there is still no available therapeutic agent for most of the viruses in clinical practice. Coumarin is a chemical compound which is found naturally in a variety of plants, it can also be synthetically produced possessing diverse biological effects. More recently, reports have highlighted the potential role of coumarin derivatives as antiviral agents. This review outlines the advances in coumarin-based compounds against various viruses including human immunodeficiency virus, hepatitis virus, herpes simplex virus, Chikungunya virus and Enterovirus 71, as well as the structure activity relationship and the possible mechanism of action of the most potent coumarin derivatives.

由病毒引起的感染是世界上发病率和死亡率的首要原因之一。尽管目前有多种抗病毒药物用于治疗各种病毒感染性疾病，但在临床实践中仍然没有针对大多数病毒的有效治疗剂。香豆素是一种天然存在于多种植物中的化合物，它也可以合成生产，具有多种生物效应。最近，报告强调了香豆素衍生物作为抗病毒剂的潜在作用。这篇综述概述了基于香豆素的化合物对抗各种病毒的进展，包括人类免疫缺陷病毒、肝炎病毒、单纯疱疹病毒、基孔肯雅病毒和肠道病毒 71，