Sex effects for the interaction of dopamine related genetic variants for COMT and BDNF on declarative memory performance,Genes, Brain and Behavior

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Sex effects for the interaction of dopamine related genetic variants for COMT and BDNF on declarative memory performance
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2021-04-19 , DOI: 10.1111/gbb.12737
Sandra Van der Auwera _{1,

2} , Jan Terock ₃ , Alexander Teumer ₄ , Georg Schomerus ₅ , Georg Homuth ₆ , Hans J Grabe _{1,

2}

Affiliation

Genetic factors are assumed to contribute to memory performance, especially genes affecting the dopaminergic neurotransmission. We aimed to evaluate leading functional genetic variants of the dopamine system, Catechol-O-methyltransferase (COMT) SNP rs4680 and Brain-derived neurotropic factor (BDNF) SNP rs6265, previously found to be associated with memory performance. In two independent general population cohorts (total N = 5937) we investigated direct and interaction effects between COMT and BDNF SNPs on declarative memory performance. We found significant two-way interactions for COMT and BDNF in both cohorts but no direct genetic effects. Sensitivity analyses revealed that an interaction between COMT and BDNF was mainly carried by females. While direct associations of COMT and BDNF on memory have been reported previously, we could demonstrate that the interaction of COMT and BDNF is sex-dependent and more complex and needs further investigation. Our results could be demonstrated in two independent cohorts of valuable size.

中文翻译：

COMT和BDNF的多巴胺相关遗传变异对陈述性记忆表现的相互作用的性别影响

遗传因素被认为有助于记忆表现，尤其是影响多巴胺能神经传递的基因。我们旨在评估多巴胺系统的主要功能遗传变异，儿茶酚-O-甲基转移酶 ( COMT ) SNP rs4680 和脑源性神经营养因子 ( BDNF ) SNP rs6265，之前发现它们与记忆性能相关。在两个独立的普通人群队列（总N = 5937）中，我们研究了COMT和BDNF SNP 之间对陈述性记忆性能的直接和相互作用影响。我们发现COMT和BDNF存在显着的双向交互在这两个队列中，但没有直接的遗传影响。敏感性分析表明，COMT和BDNF之间的相互作用主要由女性进行。虽然之前已经报道了COMT和BDNF对记忆的直接关联，但我们可以证明COMT和BDNF的相互作用是性别依赖性的，并且更复杂，需要进一步研究。我们的结果可以在两个有价值的独立队列中得到证明。

更新日期：2021-06-05

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