Abstract

Polymeric nanofibers have gained a great deal of attention in recent years. This study aims to produce and evaluate a methylcellulose (MC) and polyvinyl alcohol (PVA) based nanofibers mat using the electrospinning process. 2^5–2 fractional factorial screening design has been used to study the effect of critical formulation and process parameters, such as concentration of MC (%), the concentration of PVA (%), applied Voltage (kV), distance (cm), flow rate (ml/hr) on the critical quality attributes like fiber diameter, tensile strength, and morphology. The fiber morphology and fiber diameter of nanofibers were investigated by scanning electron microscopy (SEM).s The optimized nanofibers mat was further characterized by Fourier transform infrared (FTIR) spectroscopy, Differential scanning electrons (DSC), Thermal gravimetric analysis (TGA), X-ray diffraction (XRD), Atomic force microscopy (AFM). Parameters such as contact angle and rate of biodegradation were studied for an optimized batch. The SEM results showed the uniform morphology of optimized nanofibers without beads with fiber diameter in the range of 100–200 nm. FTIR analysis demonstrated good intermolecular interactions between the molecules of MC with PVA. DSC-TGA study showed good thermal properties of nanofibers. XRD study showed the crystalline nature of nanofibers. Maximum tensile strength up to 2.74 Mpa was obtained which is desired for drug delivery application. The exaggeration of the fiber diameter was measured by AFM and found good surface morphology. Furthermore, results of contact angle and biodegradation rate proved that prepared nanofibers would be considered as a suitable carrier for controlled drug delivery applications like wound healing.

Graphic abstract

中文翻译：

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以聚乙烯醇电纺纳米纤维为载体的载药系统共混甲基纤维素的制备与表征

摘要

近年来，聚合物纳米纤维受到了广泛的关注。这项研究旨在使用静电纺丝工艺生产和评估基于甲基纤维素（MC）和聚乙烯醇（PVA）的纳米纤维毡。2 ^5–2分数阶乘筛选设计已用于研究关键配方和工艺参数的影响，例如MC浓度（％），PVA浓度（％），施加电压（kV），距离（cm），流速（ml） / hr）的关键质量属性，例如纤维直径，拉伸强度和形态。通过扫描电子显微镜（SEM）研究了纳米纤维的纤维形态和纤维直径。通过傅立叶变换红外光谱（FTIR），差示扫描电子（DSC），热重分析（TGA），X进一步表征了优化的纳米纤维毡。射线衍射（XRD），原子力显微镜（AFM）。研究了最佳批次的接触角和生物降解速率等参数。扫描电镜结果表明，优化的纳米纤维没有纤维直径在100-200 nm范围内的珠粒，具有均匀的形貌。FTIR分析表明MC分子与PVA之间具有良好的分子间相互作用。DSC-TGA研究表明纳米纤维具有良好的热性能。XRD研究表明纳米纤维的晶体性质。获得了高达2.74 Mpa的最大拉伸强度，这是药物递送应用所希望的。通过AFM测量纤维直径的夸张，发现其具有良好的表面形态。此外，接触角和生物降解速率的结果证明，制备的纳米纤维将被认为是用于诸如伤口愈合之类的受控药物递送应用的合适载体。FTIR分析表明MC分子与PVA之间具有良好的分子间相互作用。DSC-TGA研究表明纳米纤维具有良好的热性能。XRD研究表明纳米纤维的晶体性质。获得了高达2.74 Mpa的最大拉伸强度，这是药物递送应用所希望的。通过AFM测量纤维直径的夸张，发现其具有良好的表面形态。此外，接触角和生物降解速率的结果证明，制备的纳米纤维将被认为是用于诸如伤口愈合之类的受控药物递送应用的合适载体。FTIR分析表明MC分子与PVA之间具有良好的分子间相互作用。DSC-TGA研究表明纳米纤维具有良好的热性能。XRD研究表明纳米纤维的晶体性质。获得了高达2.74 Mpa的最大拉伸强度，这是药物递送应用所希望的。通过AFM测量纤维直径的夸张，发现其具有良好的表面形态。此外，接触角和生物降解速率的结果证明，制备的纳米纤维将被认为是用于诸如伤口愈合之类的受控药物递送应用的合适载体。通过AFM测量纤维直径的夸张，发现其具有良好的表面形态。此外，接触角和生物降解速率的结果证明，制备的纳米纤维将被认为是用于诸如伤口愈合之类的受控药物递送应用的合适载体。通过AFM测量纤维直径的夸张，发现其具有良好的表面形态。此外，接触角和生物降解速率的结果证明，制备的纳米纤维将被认为是用于诸如伤口愈合之类的受控药物递送应用的合适载体。

图形摘要