Animal models are still indispensable for understanding the basic principles of glioma development and invasion. Preclinical approaches aim to analyze the treatment efficacy of new drugs before translation into clinical trials is possible. Various animal disease models are available, but not every approach is useful for addressing specific questions. In recent years, it has become increasingly evident that the tumor microenvironment plays a key role in the nature of glioma. In addition to providing an overview, this review evaluates available rodent models in terms of usability for research on the glioma microenvironment.

中文翻译：

---

用于分析胶质瘤微环境的啮齿动物模型

动物模型对于理解胶质瘤发展和侵袭的基本原理仍然是必不可少的。临床前方法旨在在转化为临床试验之前分析新药的治疗效果。有多种动物疾病模型可用，但并非每种方法都适用于解决特定问题。近年来，越来越明显的是，肿瘤微环境在胶质瘤的性质中起着关键作用。除了提供概述之外，这篇评论还评估了可用的啮齿动物模型在胶质瘤微环境研究中的可用性。