The sluggish kinetics of oxygen reduction reaction (ORR) affects the massive use of polymer exchange membrane fuel cells (PEMFCs). Therefore, the use of electrocatalysts is required to accelerate the ORR kinetics. Usually, Pt/C electrocatalysts are used for the ORR. Nevertheless, the principal disadvantages of using Pt are its high-cost, low availability, and limited stability. For these reasons, research of more stable and cost effective electrocatalysts with high electrocatalytic activity is important to achieve large-scale power generation. To date, there are significant advances and great opportunities for the design of novel electrocatalysts with high electrocatalytic activity and stability for the ORR through the connection of experimental and theoretical explorations. For these reasons, in this review, combined theoretical–experimental studies for the design of novel Pt-based metallic electrocatalysts for the ORR are revised and analyzed in detail.

氧气还原反应（ORR）的反应动力学缓慢会影响聚合物交换膜燃料电池（PEMFC）的大量使用。因此，需要使用电催化剂来加速ORR动力学。通常，Pt / C电催化剂用于ORR。但是，使用Pt的主要缺点是成本高，可用性低和稳定性有限。由于这些原因，对具有高电催化活性的更稳定和成本有效的电催化剂的研究对于实现大规模发电是重要的。迄今为止，通过实验和理论探索的结合，对于ORR具有高电催化活性和稳定性的新型电催化剂的设计具有重大的进展和巨大的机会。由于这些原因，在此评论中，