Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually. Excessive reactive oxygen species (ROS) produced through internal or external environmental influences can lead to lipid peroxidation, protein denaturation, and even DNA damage, and ultimately have harmful effects on cells. Aiming to sufficiently contact with the wound microenvironment and scavenge ROS, superabsorbent poly (acrylic acid) and antioxidant poly (ester amide) (PAA/PEA) hybrid hydrogel has been developed to enhance wound healing. The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared (FTIR) absorption spectrum, compression, swelling, degradation, etc. Besides, the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment, and corresponding antioxidant indicators have been tested at the cellular level. Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts, as well as accelerated angiogenesis and skin regeneration in wounds. The healing properties of wounds in vivo were further assessed on mouse skin wounds. Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization. In summary, these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.

中文翻译：

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用于促进伤口愈合的高吸水性聚（丙烯酸）和抗氧化聚（酯酰胺）混合水凝胶

由于每年大量的皮肤损伤，临床上越来越需要伤口愈合敷料。通过内部或外部环境影响产生的过量活性氧（ROS）会导致脂质过氧化、蛋白质变性，甚至DNA损伤，最终对细胞产生有害影响。为了与伤口微环境充分接触并清除 ROS，已开发出高吸水性聚（丙烯酸）和抗氧化性聚（酯酰胺）（PAA/PEA）混合水凝胶以促进伤口愈合。通过傅里叶变换红外（FTIR）吸收光谱、压缩、溶胀、降解等研究杂化水凝胶的物理和化学性质。此外，杂化水凝胶的抗氧化性能可以通过自由基清除实验研究，并在细胞水平上测试了相应的抗氧化指标。混合水凝胶支架支持人脐静脉内皮细胞和成纤维细胞的增殖，以及加速伤口中的血管生成和皮肤再生。在小鼠皮肤伤口上进一步评估了体内伤口的愈合特性。结果表明，PAA/PEA 混合水凝胶支架通过增强肉芽形成和上皮再形成显着加速了伤口愈合过程。总之，这些超强吸收和抗氧化的混合水凝胶可以作为一种极好的伤口敷料，用于全层伤口愈合。以及加速伤口中的血管生成和皮肤再生。在小鼠皮肤伤口上进一步评估了体内伤口的愈合特性。结果表明，PAA/PEA 混合水凝胶支架通过增强肉芽形成和上皮再形成显着加速了伤口愈合过程。总之，这些超强吸收和抗氧化的混合水凝胶可以作为一种极好的伤口敷料，用于全层伤口愈合。以及加速伤口中的血管生成和皮肤再生。在小鼠皮肤伤口上进一步评估了体内伤口的愈合特性。结果表明，PAA/PEA 混合水凝胶支架通过增强肉芽形成和上皮再形成显着加速了伤口愈合过程。总之，这些超强吸收和抗氧化的混合水凝胶可以作为一种极好的伤口敷料，用于全层伤口愈合。