Increased numbers of circulating microparticles (MPs) have long been documented in thalassemia and are considered as a contributing factor in developing the thromboembolic events (TEEs), which are associated with endothelial dysfunction. Indeed, the cellular and molecular mechanisms by which MPs and endothelial cells interact and their consequences remain poorly investigated.

中文翻译：

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细胞源性微粒的内化触发内皮促炎症反应。


长期以来，地中海贫血症中循环微粒（MP）数量的增加被认为是导致血栓栓塞事件（TEE）的一个促成因素，而血栓栓塞事件与内皮功能障碍有关。事实上，MP 和内皮细胞相互作用的细胞和分子机制及其后果仍然缺乏研究。