Background

exercise stimulates growth hormone (GH) secretion and may serve as a promising physiological test for the diagnosis of GH deficiency. However, exercise standardization for a feasible GH test is still lacking. The aim of the present study was to examine the GH secretion to high intensity interval exercise.

Methods

Seventeen children (12.4 ± 2.6 years) with impaired growth rate performed high-intensity interval exercise test (HIIE) that included 10 intervals of 15 s all out pedaling against resistance determined by age, sex and weight on a cycle ergometer with 1-min active rest between each interval. Power output measurements were collected during the test. Blood samples were collected before, immediately after, 30, 45, and 60 min after the beginning of the exercise test. GH response was compered to pharmacological provocation test (clonidine or glucagon).

Results

HIIE led to a significant increase in GH levels (p < 0.001), with high correlation to GH response following pharmacological stimulation (r = 0.82, r = 0.80 for clonidine and glucagon respectively, p < 0.001) A significant correlation was found between mean peak power to body weight and the GH response (r = 0.50, p = 0.04). 83% of the participants who reached peak power > 10 watts/kg had normal GH secretion.

Conclusions

HIIE is a brief and individualized exercise protocol that may be used as a physiological provocation test for GH secretion. There might be a minimum of anaerobic power needed to induce adequate GH response during HIIE.

中文翻译：

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高强度间歇运动试验刺激儿童生长激素分泌

背景

运动刺激生长激素 (GH) 分泌，可作为诊断 GH 缺乏的有希望的生理测试。然而，仍然缺乏可行的 GH 测试的运动标准化。本研究的目的是检查高强度间歇运动的 GH 分泌。

方法

17 名生长速度受损的儿童 (12.4 ± 2.6 岁) 进行了高强度间歇运动测试 (HIIE)，其中包括 10 次 15 秒的间隔，在 1 分钟活动的自行车测力计上针对年龄、性别和体重确定的阻力全部踩踏在每个间隔之间休息。在测试期间收集功率输出测量值。在运动试验开始后的30、45 和 60 分钟之前、之后立即采集血样。GH反应通过药理学激发试验（可乐定或胰高血糖素）进行。

结果

HIIE 导致 GH 水平显着增加 ( p  < 0.001)，与药物刺激后的 GH 反应高度相关（ 可乐定和胰高血糖素分别为r  = 0.82，r = 0.80， p  < 0.001）发现平均峰之间存在显着相关性对体重的影响和 GH 反应 ( r  = 0.50, p  = 0.04)。达到峰值功率 > 10 瓦/公斤的参与者中有 83% 的 GH 分泌正常。

结论

HIIE 是一种简短且个性化的运动方案，可用作 GH 分泌的生理激发测试。在 HIIE 期间，可能需要最低限度的无氧能量来诱导足够的 GH 反应。