Background: The elevated global burden of the breast invasive carcinoma (BRIC) and lack of appropriate biomarkers for its early detection and treatment requires extensive investigation to enhance understanding regarding BRIC associated molecular alterations. Ataxia telangiectasia mutated (ATM) is a multifunctional tumor suppressor gene, which participates in the DNA damage response pathway and cellular checkpoint activation. Several studies have reported the reduction of ATM expression as a reliable biomarker of BRIC. However, its role as a clinicopathological feature-specific biomarker still needs to be explored.

中文翻译：

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在多组学数据的计算机分析中确定共济失调性毛细血管扩张症突变基因是乳腺癌浸润性癌的潜在生物标志物

背景：乳腺癌浸润性癌 (BRIC) 的全球负担升高，并且缺乏用于其早期检测和治疗的适当生物标志物，需要进行广泛的调查，以增强对 BRIC 相关分子改变的了解。共济失调毛细血管扩张突变（ ATM）是一种多功能抑癌基因，参与DNA损伤反应通路和细胞检查点激活。几项研究报告了ATM表达的减少作为 BRIC 的可靠生物标志物。然而，其作为临床病理特征特异性生物标志物的作用仍有待探索。