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Hematocrit-Related Alterations of Circulating microRNA-21 Levels in Heart Failure Patients with Reduced Ejection Fraction: A Preliminary Study
Genetic Testing and Molecular Biomarkers ( IF 1.1 ) Pub Date : 2021-04-19 , DOI: 10.1089/gtmb.2020.0277
Viera Nemcekova 1, 2 , Zuzana Kmecova 1 , Lenka Bies Pivackova 1 , Eva Goncalvesova 3, 4 , Peter Krenek 1 , Gabriel Doka 1 , Jan Klimas 1
Affiliation  

Aim: Circulating microRNA-21 (miR-21) has been utilized as a diagnostic tool in the assessment of heart failure (HF). Blood constitution may be altered when HF occurs and miR-21 may affect hematopoiesis. Sample hemolysis may influence the determination of circulating miRNAs, challenging the diagnostic use of miRNAs.

中文翻译:

射血分数降低的心力衰竭患者循环 microRNA-21 水平的血细胞比容相关变化:一项初步研究

目的:循环 microRNA-21 (miR-21) 已被用作评估心力衰竭 (HF) 的诊断工具。发生 HF 时,血液构成可能会发生改变,而 miR-21 可能会影响造血功能。样本溶血可能会影响循环 miRNA 的测定,从而对 miRNA 的诊断应用提出挑战。
更新日期:2021-04-20
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