Aim: Circulating microRNA-21 (miR-21) has been utilized as a diagnostic tool in the assessment of heart failure (HF). Blood constitution may be altered when HF occurs and miR-21 may affect hematopoiesis. Sample hemolysis may influence the determination of circulating miRNAs, challenging the diagnostic use of miRNAs.

中文翻译：

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射血分数降低的心力衰竭患者循环 microRNA-21 水平的血细胞比容相关变化：一项初步研究

目的：循环 microRNA-21 (miR-21) 已被用作评估心力衰竭 (HF) 的诊断工具。发生 HF 时，血液构成可能会发生改变，而 miR-21 可能会影响造血功能。样本溶血可能会影响循环 miRNA 的测定，从而对 miRNA 的诊断应用提出挑战。