Bipolar disorder (BD) is associated with a range of social cognitive deficits. This study investigated the functioning of the mentalizing brain system in BD probed by an eye gaze perception task during fMRI. Compared with healthy controls (n = 21), BD participants (n = 14) showed reduced preferential activation for self-directed gaze discrimination in the medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ), which was associated with poorer cognitive and social functioning. Aberrant functions of the mentalizing system should be further investigated as marker of social dysfunction and treatment targets.

中文翻译：

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在双相情感障碍的视线辨别过程中，诱人的脑系统异常激活。

躁郁症（BD）与一系列社会认知缺陷有关。这项研究调查了功能性磁共振成像过程中通过视线感知任务探测到的BD脑中脑部系统的功能。与健康对照组（n = 21）相比，BD参与者（n = 14）显示内侧前额叶皮层（mPFC）和颞顶叶连接（TPJ）中针对自我指导的凝视辨别的优先激活减少，这与较差的认知能力有关和社会功能。应该进一步研究心理系统的异常功能，将其作为社会功能障碍和治疗目标的标志。