Most studies on arsenic toxicity have been conducted among populations exposed to arsenic contained in drinking water. Relatively little research concerns effects of airborne arsenic. The aim of this study was to determine whether there is an association between urinary 15-F2t-isoprostane (u15-F2t-IsoP) levels in relation to renal function (urinary creatinine and N-acetyl-β-d-glucosaminidase––uNAG) and urinary arsenic (uAs) in inhabitants from copper smelter impact zone. The secondary purpose of the analysis was to assess utility of a potential association between uAs and u15-F2t-IsoP as a biomarker of systemic oxidative stress. Urinary 15-F2t-IsoP, NAG, and creatinine were measured in 967 urine samples collected from 649 adult women (51.9 ± 13.2 years old) and 318 adult men (53.8 ± 14.9 years old). Total uAs concentration was measured in 918 samples using HPLC-ICP-MS. Arsenic species, such as inorganic arsenic, methylarsonic acid, dimethylarsinic acid, and arsenobetaine, were measured in urine collected from 255 participants with uAs exceeding the upper norm. Data were analyzed using multivariate linear regression and logistic regression models. In the studied population urinary creatinine was positively associated with uAs. A positive linear correlation (p < 0.0000) between lg(uAs) and u15-F2t-IsoP was found both for normal and elevated uAs. A positive linear correlation was observed also between lg(ΣuAs) and u15-F2t-IsoP (p < 0.0000). In the logistic regression model, after adjustment for confounders, elevated uAs was the only predictor of increased u15-F2t-IsoP (OR = 1.31, 95% CI 1.08–1.59, p < 0.01). Cigarette smoking was associated with renal proximal tubular dysfunction only in people with uNAG concentration above 75th quartile. In the studied population chronically exposed to airborne arsenic, increase in urinary arsenic is associated with renal dysfunction and systemic oxidative stress. Urinary 15-F2t-isoprostane may be useful in the monitoring of health status in populations exposed to airborne arsenic.

关于砷毒性的大多数研究都是在饮用水中接触砷的人群中进行的。相对较少的研究关注机载砷​​的影响。这项研究的目的是确定尿15-F2t-异前列腺素（u15-F2t-IsoP）水平与肾功能（尿肌酐和N-乙酰基-β- d）之间是否存在关联-铜冶炼厂影响区居民中的-氨基葡萄糖苷酶-uNAG）和尿砷（uAs）。分析的第二个目的是评估uAs和u15-F2t-IsoP之间潜在的关联作为系统性氧化应激的生物标志物的效用。在从649名成年女性（51.9±13.2岁）和318名成年男性（53.8±14.9岁）收集的967个尿液样本中，测量了尿液15-F2t-IsoP，NAG和肌酐。使用HPLC-ICP-MS测定了918个样品中的总uAs浓度。在从255名uA超过最高标准的参与者收集的尿液中测量了砷物种，例如无机砷，甲基砷酸，二甲基砷酸和砷甜菜碱。使用多元线性回归和逻辑回归模型分析数据。在研究人群中，尿肌酐与uAs呈正相关。正线性相关（ 对于正常和升高的uAs，在lg（uAs）和u15-F2t-IsoP之间发现p <0.0000）。在lg（ΣuAs）和u15-F2t-IsoP之间也观察到正线性相关（p  <0.0000）。在逻辑回归模型中，对混杂因素进行调整后，uAs升高是u15-F2t-IsoP升高的唯一预测因子​​（OR = 1.31，95％CI 1.08–1.59，p  <0.01）。仅在uNAG浓度高于第75个四分位数的人群中，吸烟与肾近端肾小管功能障碍有关。在长期暴露于空气传播的砷的研究人群中，尿砷的增加与肾功能不全和全身性氧化应激有关。尿15-F2t-异前列腺素可能有助于监测暴露于空气中砷的人群的健康状况。