Magnesium status and vitamin B6 intake have been linked to mental health and/or quality of life (QoL). In an 8-week Phase IV randomised controlled study in individuals with low magnesemia and severe/extremely severe stress but who were otherwise healthy, greater stress reduction was achieved with magnesium combined with vitamin B6 than with magnesium alone. We present a previously unreported secondary analysis of the effect of magnesium, with and without vitamin B6, on depression, anxiety, and QoL. Adults with Depression Anxiety Stress Scales (DASS-42) stress subscale score >18 were randomised 1:1 to magnesium + vitamin B6 combination (Magne B6^®; daily dose 300 and 30 mg, respectively) or magnesium alone (Magnespasmyl^®; daily dose 300 mg). Outcomes included changes from baseline in DASS-42 depression and anxiety scores, and QoL (Short Form-36 Health Survey). DASS-42 anxiety and depression scores significantly improved from baseline to week 8 with both treatments, particularly during the first 4 weeks. Improvement in QoL continued over 8 weeks. Participants' perceived capacity for physical activity in daily life showed greater improvement with magnesium + vitamin B6 than magnesium alone (Week 4). In conclusion, magnesium supplementation, with or without vitamin B6, could provide a meaningful clinical benefit in daily life for individuals with stress and low magnesemia.

中文翻译：

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镁和维生素 B6 补充剂对压力健康成年人心理健康和生活质量的影响：随机对照试验的事后分析

镁状态和维生素 B6 摄入量与心理健康和/或生活质量 (QoL) 相关。在一项为期 8 周的 IV 期随机对照研究中，对低镁血症和重度/极度重度压力但其他方面健康的个体进行的研究表明，与单独使用镁相比，镁与维生素 B6 的组合可以更大程度地减轻压力。我们对镁（含或不含维生素 B6）对抑郁、焦虑和生活质量的影响进行了先前未报道的二次分析。抑郁焦虑压力量表 (DASS-42) 压力子量表得分 >18 的成年人以 1:1 的比例随机分配到镁 + 维生素 B6 组合（Magne B6 ^®；日剂量分别为 300 和 30 mg）或单独使用镁（Magnespasmyl ^®; 每日剂量 300 毫克）。结果包括 DASS-42 抑郁和焦虑评分和 QoL（Short Form-36 健康调查）的基线变化。从基线到第 8 周，两种治疗的 DASS-42 焦虑和抑郁评分显着改善，特别是在前 4 周。QoL 的改善持续了 8 周。参与者对日常生活中身体活动的感知能力与单独使用镁（第 4 周）相比，镁 + 维生素 B6 的改善更大。总之，镁补充剂，无论是否含有维生素 B6，都可以在日常生活中为有压力和低镁血症的个体提供有意义的临床益处。