Peripheral neurons (including sensory neurons) are ubiquitously distributed in all tissues, particularly at the interface with the environment. The primary function of sensory neurons is the transmission of sensations of temperature, pain and itch to elicit appropriate behavioral responses. More recently, sensory neurons have emerged as potent regulators of type 2 immune responses and allergic inflammation. There is increasing evidence showing that neurons can express receptors previously thought to be restricted to the immune compartment. In addition, certain subtypes of immune cells (e.g. mast cells, ILC2s or macrophages) also express specific neuroreceptors that provide them with the capacity to integrate neuron-derived signals and modulate their activation status during the development of allergic inflammation.

外周神经元（包括感觉神经元）普遍分布在所有组织中，特别是在与环境的界面处。感觉神经元的主要功能是传递温度、疼痛和瘙痒的感觉，以引发适当的行为反应。最近，感觉神经元已成为 2 型免疫反应和过敏性炎症的有效调节剂。越来越多的证据表明神经元可以表达以前被认为仅限于免疫区室的受体。此外，某些免疫细胞亚型（例如肥大细胞、ILC2 或巨噬细胞）也表达特定的神经受体，这些神经受体为它们提供整合神经元衍生信号并在过敏性炎症发展过程中调节其激活状态的能力。