Better management of persistent pulmonary hypertension of neonates (PPHN) required new markers that can predict the response of patient to treatment and thus influence the medical decision to avoid short-term and long-term adverse effects. Hence, we aimed to evaluate B-natriuretic peptide (BNP) serum levels in neonates with PPHN and to correlate its levels with disease severity and response to treatment. The study included 60 neonates (30 PPHN patients and 30 healthy subjects). BNP was assessed, using the ELISA technique, at admission and after 4 days of treatment. Initial serum BNP levels were significantly higher in patients compared to controls (p < 0.001). Patients with mild severity showed lower BNP levels compared to patients with moderate severity, while patients with moderate severity showed decreased levels in comparison to severe cases (p < 0.001). The group of patients who showed remission after 4 days of treatment had lower pre-treatment and post-treatment BNP levels, compared to patients who showed incomplete remission. Initial levels of BNP showed strong positive correlations with pulmonary artery pressure (PAP) and oxygenation index (OI) before treatment (r = 0.9, p < 0.001 and r = 0.85, p = 0.001), while BNP after treatment showed moderate positive correlations with PAP before treatment (r = 0.6, p = 0.001) and OI before treatment (r = 0.6, p = 0.001). Analysis of the ROC curve revealed an AUC of 0.83with CI = 0.7–0.98 and p = 0.003. BNP may play a role in the pathogenesis of PPHN, and BNP serum level can be used as a marker to detect disease severity and predict response to treatment.

中文翻译：

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持续性肺动脉高压新生儿的B钠尿肽血清水平

新生儿持续性肺动脉高压（PPHN）的更好管理需要新的标记物，这些标记物可以预测患者对治疗的反应，从而影响医疗决策，从而避免短期和长期的不良反应。因此，我们旨在评估患有PPHN的新生儿的B型钠尿肽（BNP）血清水平，并将其水平与疾病严重程度和对治疗的反应相关联。该研究包括60名新生儿（30名PPHN患者和30名健康受试者）。在入院时和治疗4天后，使用ELISA技术评估BNP。与对照组相比，患者的初始血清BNP水平显着更高（p <0.001）。重度轻度患者的BNP水平低于重度中度患者，而严重程度中等的患者与严重病例相比水平降低（p <0.001）。与未完全缓解的患者相比，治疗4天后缓解的患者组的治疗前和治疗后BNP水平较低。治疗前BNP的初始水平与肺动脉压（PAP）和氧合指数（OI）呈强正相关（r = 0.9，p <0.001和r = 0.85，p = 0.001），而治疗后BNP与肺动脉压（P = 0.001）呈中等正相关。治疗前PAP（r = 0.6，p = 0.001）和治疗前OI（r = 0.6，p = 0.001）。ROC曲线分析显示AUC为0.83，CI = 0.7-0.98，p = 0.003。BNP可能在PPHN的发病机理中起作用，