The mismatch negativity (MMN), an electrophysiological response to an oddball auditory stimulus, is related to reading ability in many studies. There are conflicting findings regarding exactly how the MMN relates to risk or actual diagnosis of dyslexia/reading impairment, perhaps due to the heterogeneity of abilities in children with reading impairment. In this study, 166 English-speaking kindergarten children oversampled for dyslexia risk completed behavioral assessments and a speech-syllable MMN paradigm. We examined how early and late MMN mean amplitude and laterality were related to two established predictors of reading ability: phonological awareness (PA) and rapid automatized naming (RAN). In bootstrapped group analyses, late MMN amplitude was significantly greater in children with typical PA ability than low PA ability. In contrast, laterality of the early and late MMN was significantly different in children with low versus typical with RAN ability. Continuous analyses controlling for child age, nonverbal IQ, and letter and word identification abilities showed the same associations between late MMN amplitude with PA and late MMN laterality with RAN. These findings suggest that amplitude of the MMN may relate to phonological representations and ability to manipulate them, whereas MMN laterality may reflect differences in brain processes that support automaticity needed for reading.

中文翻译：

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ERP 失配负幅和不对称反映了英语幼儿园儿童的语音和快速自动命名技能


失配负性（MMN）是一种对奇怪听觉刺激的电生理反应，在许多研究中与阅读能力有关。关于 MMN 与阅读障碍/阅读障碍的风险或实际诊断的确切关系，存在相互矛盾的发现，这可能是由于阅读障碍儿童的能力存在异质性。在这项研究中，166 名讲英语的幼儿园儿童因阅读障碍风险而被过度采样，并完成了行为评估和语音音节 MMN 范式。我们研究了早期和晚期 MMN 平均振幅和偏侧性与两个既定的阅读能力预测因素的关系：语音意识 (PA) 和快速自动命名 (RAN)。在自举组分析中，具有典型 PA 能力的儿童的晚期 MMN 振幅明显大于低 PA 能力的儿童。相比之下，早期和晚期 MMN 的偏侧性在 RAN 能力较低的儿童与典型的 RAN 能力儿童中显着不同。控制儿童年龄、非语言智商以及字母和单词识别能力的连续分析表明，晚期 MMN 振幅与 PA 以及晚期 MMN 偏侧性与 RAN 之间存在相同的关联。这些发现表明，MMN 的幅度可能与语音表征和操纵它们的能力有关，而 MMN 的偏侧性可能反映了支持阅读所需自动性的大脑过程的差异。