Active dry powder inhalers (DPIs) actuated by low air volume provide distinct advantages for delivering aerosols to patients with poor respiratory capacity. This work aims to investigate the effects of piercing aperture location and inlet flow rate on device-emptying, and to identify the mechanism of particle deposition in a realistic mouth-throat (MT) region. Computational fluid dynamics (CFD) is employed to predict dispersion parameters that measure turbulence intensity, and mono-sized particles are tracked by the discrete phase model (DPM). Results show that the piercing aperture location and the inlet flow rate both have significant impacts on device emptying. Strong correlations have been established between the emitted dose and flow field parameters. The pattern and distribution of the deposited particles in the realistic MT region are highly sensitive to particle size, flow rate and reservoir length. This work provides profound insights into the performance of the active DPIs and an additional perspective on device design.

低风量致动的主动干粉吸入器（DPI）为向呼吸能力较差的患者提供气雾剂提供了明显的优势。这项工作的目的是调查穿孔的位置和入口流速对设备排空的影响，并确定在真实的喉咙（MT）区域中颗粒沉积的机制。计算流体动力学（CFD）用于预测测量湍流强度的弥散参数，离散相模型（DPM）跟踪单尺寸颗粒。结果表明，穿刺孔的位置和入口流速都对设备排空有重大影响。在发射剂量和流场参数之间已经建立了很强的相关性。实际MT区域中沉积颗粒的图案和分布对颗粒大小，流速和储层长度高度敏感。这项工作为活动DPI的性能提供了深刻的见解，并为设备设计提供了新的视角。