ABSTRACT

Background: Left ventricular hypertrophy (LVH) is an endpoint of hypertensive cardiac alterations. Renin-angiotensin-aldosterone system (RAAS) blockers are among the most effective on LVH regression. Physical exercise combined to antihypertensive drug contributes to arterial pressure (AP) control and LVH prevention. We evaluated the effects of physical exercise combined to captopril or losartan during eight weeks for spontaneously hypertensive rats (SHR) on some cardiac parameters.

Methods: SHR (n=5-6 per group) were sedentary or trained 5 days a week in treadmill during 8 weeks; and they were treated with daily oral captopril (12.5, 25, or 50mg/kg), losartan (2.5, 5, or 10mg/kg), or vehicle. At the end, it was obtained systolic AP (SAP), electrocardiogram (ECG), and hearts metalloproteinase 2 (MMP-2) activity and histology.

Results: Captopril 25 and 50 mg/kg, and losartan 10 mg/kg lowered SAP of sedentary and trained SHR. Losartan 5 mg/kg combined with physical exercise also lowered SAP. Combined with exercise, captopril 50 mg/kg lowered 13.6% of QT interval, 14.2% of QTc interval, and 22.8% of Tpeak-Tend compared to sedentary SHR. Losartan 5 and 10mg/kg lowered QT interval of sedentary and trained SHR. Losartan 2.5, 5 and 10mg/kg combined with physical exercise lowered respectively 25.4%, 24.8%, and 31.8% of MMP-2 activity. Losartan (10mg/kg) combined with exercise reduced cardiomyocyte diameter.

Conclusion: These data support the hypothesis of physical exercise combined with RAAS blockers could improve the benefits on hypertensive LVH treatment.

摘要

背景：左心室肥厚 (LVH) 是高血压心脏改变的终点。肾素-血管紧张素-醛固酮系统 (RAAS) 阻滞剂是对 LVH 消退最有效的药物之一。体育锻炼与抗高血压药物相结合有助于控制动脉压 (AP) 和预防 LVH。我们评估了自发性高血压大鼠 (SHR) 八周内体育锻炼联合卡托普利或氯沙坦对某些心脏参数的影响。

方法： SHR（每组n=5-6）在8周内每周5天在跑步机上久坐或训练；他们每天口服卡托普利（12.5、25 或 50 毫克/千克）、氯沙坦（2.5、5 或 10 毫克/千克）或赋形剂。最后，获得收缩期 AP (SAP)、心电图 (ECG) 和心脏金属蛋白酶 2 (MMP-2) 活性和组织学。

结果：卡托普利 25 和 50 mg/kg 以及氯沙坦 10 mg/kg 降低了久坐和训练有素的 SHR 的 SAP。氯沙坦 5 mg/kg 结合体育锻炼也降低了 SAP。结合运动，与久坐的 SHR 相比，卡托普利 50 mg/kg 降低了 13.6% 的 QT 间期、14.2% 的 QTc 间期和 22.8% 的 Tpeak-Tend。氯沙坦 5 和 10mg/kg 降低久坐和训练过的 SHR 的 QT 间期。氯沙坦2.5、5和10mg/kg联合体育锻炼分别使MMP-2活性降低25.4%、24.8%和31.8%。氯沙坦 (10mg/kg) 结合运动可减少心肌细胞直径。

结论：这些数据支持体育锻炼联合 RAAS 阻滞剂可以改善高血压 LV​​H 治疗获益的假设。