Aim

To elucidate the morphological characteristics of spike-wave complexes (SWCs) causing myoclonic seizures (MS) in childhood-onset idiopathic myoclonic epilepsies.

Subjects and Methods

The subjects were 8 patients, including 4 with epilepsy with myoclonic-atonic seizures (EMAS), 3 with myoclonic epilepsy in infancy (MEI) and 1 with idiopathic unclassifiable myoclonic epilepsy. Morphometric parameters of the SWCs were compared between those with MS [SWC-MS (+)] and those without MS [SWC-MS (-)], and a correlation coefficient analysis was performed between the SWC parameters and the duration of myoclonic electromyogram (EMG) potentials.

Results

A total of 155 SWC-MS (+) (range: 7 ∼ 34) and 80 SWC-MS (-) (10 each as a control) were analyzed. Comparison of the parameters of the SWCs between SWC-MS (+) and SWC-MS (-) demonstrated that the depth and the width of the positive-sharp-components (PSC) in the SWC-MS (+) were significantly deeper in amplitude and longer in duration than those in the SWC-MS (-), respectively, in all 8 patients (P < 0.05), whereas the number of the polyphasic-multiple-spike-components (PMSC) and the height of negative-spike-components (NSC) were not significantly different in most of the patients, respectively. The depth and the width of PSC were also significantly correlated with the duration of myoclonic EMG potentials in all patients except one [depth of PSC (n = 7): r = 0.623 ∼ 0.888; width of PSC (n = 8): r = 0.676 ∼ 0.948, P < 0.05].

Conclusions

This study revealed that the depth and width of PSC of the SWC are positively correlated with the MS intensity in childhood-onset idiopathic myoclonic epilepsies and are an important neurophysiological marker to generate MS.

中文翻译：

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导致特发性肌阵挛性癫痫儿童肌阵挛性癫痫发作的棘波复合物 (SWC) 的形态测量分析——SWC 阳性成分与肌阵挛强度相关

目标

阐明在儿童期特发性肌阵挛癫痫中引起肌阵挛发作 (MS) 的棘波复合物 (SWC) 的形态学特征。

主题和方法

研究对象为 8 名患者，其中 4 名患有肌阵挛性失张力性癫痫（EMAS），3 名患有婴儿期肌阵挛性癫痫（MEI），1 名患有无法分类的特发性肌阵挛性癫痫。比较有MS[SWC-MS (+)]和没有MS[SWC-MS (-)]的SWCs的形态学参数，并在SWC参数和肌阵挛肌电图持续时间之间进行相关系数分析。 EMG) 电位。

结果

总共分析了 155 个 SWC-MS (+) (范围：7 ∼ 34) 和 80 个 SWC-MS (-) (各 10 个作为对照)。SWC-MS (+) 和 SWC-MS (-) 之间的 SWC 参数比较表明，SWC-MS (+) 中的正锐分量 (PSC) 的深度和宽度明显更深在所有 8 例患者中，波幅和持续时间分别比 SWC-MS (-) 更长（P < 0.05），而多相多尖峰成分（PMSC）的数量和负尖峰的高度- 成分（NSC）分别在大多数患者中没有显着差异。PSC 的深度和宽度也与所有患者的肌阵挛 EMG 电位持续时间显着相关，除了一个 [PSC 深度（n = 7）：r = 0.623 ∼ 0.888；PSC 的宽度 (n = 8): r = 0.676 ∼ 0.948, P < 0.05]。

结论

本研究表明，SWC 的 PSC 深度和宽度与儿童期特发性肌阵挛性癫痫的 MS 强度呈正相关，是产生 MS 的重要神经生理标志物。