The emergence of endo-lysosomes as ubiquitous Ca²⁺ stores with their unique cohort of channels has resulted in their being implicated in a growing number of processes in an ever-increasing number of cell types. The architectural and regulatory constraints of these acidic Ca²⁺ stores distinguishes them from other larger Ca²⁺ sources such as the ER and influx across the plasma membrane. In view of recent advances in the understanding of the modes of operation, we discuss phagocytosis as a template for how endo-lysosomal Ca²⁺ signals (generated via TPC and TRPML channels) can be integrated in multiple sophisticated ways into biological processes. Phagocytosis illustrates how different endo-lysosomal Ca²⁺ signals drive different phases of a process, and how these can be altered by disease or infection.

内溶酶体作为普遍存在的 Ca ²⁺存储体的出现及其独特的通道队列导致它们涉及越来越多的细胞类型中越来越多的过程。这些酸性 Ca ²⁺存储的结构和监管限制将它们与其他较大的 Ca ²⁺来源（例如 ER 和跨质膜流入）区分开来。鉴于对操作模式的理解的最新进展，我们讨论了吞噬作用作为如何以多种复杂方式将内溶酶体 Ca ²⁺信号（通过 TPC 和 TRPML 通道产生）整合到生物过程中的模板。吞噬作用说明了不同的内-溶酶体 Ca ²⁺信号驱动一个过程的不同阶段，以及疾病或感染如何改变这些阶段。