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Histone PTM Crosstalk Stimulates Dot1 Methyltransferase Activity
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2021-04-17 , DOI: 10.1016/j.tibs.2021.04.001
Jevon A Cutler 1 , Florian Perner 2 , Scott A Armstrong 3
Affiliation  

Valencia-Sánchez et al. have demonstrated that two histone post-translational modifications (PTMs) – H4K16 acetylation (H4K16ac) and H2BK120 ubiquitination (H2Bub) – enhance the methylation of H3K79 (H3K79me) by Dot1. This breakthrough indicates crosstalk between H4Kac/H2Bub/H3K79me and may improve our understanding of the role that Dot1/Dot1L plays in developmental processes and disease, including MLL1/KMT2A(MLL-r) leukemia.



中文翻译:


组蛋白 PTM 串扰刺激 Dot1 甲基转移酶活性



巴伦西亚-桑切斯等人已经证明,两种组蛋白翻译后修饰 (PTM) – H4K16 乙酰化 (H4K16ac) 和 H2BK120 泛素化 (H2Bub) – 增强了 Dot1 对 H3K79 (H3K79me) 的甲基化。这一突破表明 H4Kac/H2Bub/H3K79me 之间存在串扰,并可能提高我们对 Dot1/Dot1L 在发育过程和疾病(包括 MLL1/ KMT2A ( MLL-r ) 白血病)中所起作用的理解。

更新日期:2021-06-10
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