Nocturnal hypoxia occurring in obstructive sleep apnea (OSA) is associated with different metabolic disturbances. The present study aims to correlate between nocturnal oxygen desaturation and levels of glycemic control in patients with type 2 diabetes mellitus (T2DM) and undiagnosed OSA. The present study included 107 patients with T2DM referred for assessment of sleep-related breathing disorder, there were 62 males (57.94%) and 45 females (42.05%), and their age ranged from 42 to 72 years with an average age of 61.29 ± 6.68 years. The patients were divided into 2 groups according to the results of overnight pulse oximetry (OPO) and apnea-hypopnea index (AHI) detected by polysomnography. Group 1 included 68 patients, they had moderate to severe OSA and significant nocturnal desaturation, and group 2 included 39 patients with no or mild OSA. The baseline characteristics of the two groups were not significantly different. Group 1 patients showed significantly higher mean Epworth score and more symptoms related to OSA. There was statistically significant difference between the values of ODI (24.88 ± 9.21 versus 8.94 ± 2.38), AHI (27.10 ± 7.68 versus 9.02 ± 3.90), and hemoglobin A1c levels (8.04 ± 0.64 versus 6.79 ± 0.38) between the two groups. A positive correlation was found between nocturnal oxygen desaturation and levels of HbA1c in group 1 patients reflecting worse glycemic control in patients with moderate to severe OSA. Nocturnal oxygen desaturation occurring in obstructive sleep apnea is associated with poor glycemic control in patients with type 2 diabetes mellitus. ClinicalTrials.gov , Protocol ID: OPO10-18. Trial registry number: NCT04711083 . Date of registration: 14 January 2021, retrospectively registered.

中文翻译：

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糖尿病阻塞性睡眠呼吸暂停患者夜间血氧饱和度与血糖控制的相关性

阻塞性睡眠呼吸暂停（OSA）中发生的夜间缺氧与不同的代谢紊乱有关。本研究旨在将2型糖尿病（T2DM）和未确诊OSA患者的夜间氧饱和度降低与血糖控制水平相关联。本研究纳入107例T2DM患者以评估与睡眠有关的呼吸障碍，其中男性62例（57.94％），女性45例（42.05％），年龄在42至72岁之间，平均年龄为61.29± 6.68年。根据多导睡眠图检测过夜脉搏血氧饱和度（OPO）和呼吸暂停低通气指数（AHI）的结果将患者分为两组。第1组包括68例患者，他们患有中度至重度OSA和严重的夜间脱饱和，第2组包括39例无或轻度OSA的患者。两组的基线特征无显着差异。第1组患者显示出较高的平均Epworth评分和更多与OSA相关的症状。两组之间的ODI值（24.88±9.21对8.94±2.38），AHI（27.10±7.68对9.02±3.90）和血红蛋白A1c水平（8.04±0.64对6.79±0.38）之间存在统计学差异。在第1组患者中，夜间氧饱和度与HbA1c水平呈正相关，这反映了中度至重度OSA患者的血糖控制较差。在2型糖尿病患者中，阻塞性睡眠呼吸暂停引起的夜间氧饱和度降低与血糖控制不良有关。ClinicalTrials.gov，协议ID：OPO10-18。试用注册号：NCT04711083。注册日期：