Recent developments of organoids engineering and organ-on-a-chip microfluidic technologies have enabled the recapitulation of the major functions and architectures of microscale human tissue, including tumor pathophysiology. Nevertheless, there remain challenges in recapitulating the complexity and heterogeneity of tumor microenvironment. The integration of these engineering technologies suggests a potential strategy to overcome the limitations in reconstituting the perfusable microvascular system of large-scale tumors conserving their key functional features. Here, we review the recent progress of in vitro tumor-on-a-chip microfluidic technologies, focusing on the reconstruction of microvascularized organoid models to suggest a better platform for personalized cancer medicine.

中文翻译：

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微血管化肿瘤类器官芯片：推进具有病理生理学相关性的临床前药物筛选

类器官工程和芯片上器官微流体技术的最新发展使得能够重述微型人体组织的主要功能和结构，包括肿瘤病理生理学。然而，概括肿瘤微环境的复杂性和异质性仍然存在挑战。这些工程技术的整合提出了一种潜在的策略，可以克服重建大型肿瘤的可灌注微血管系统的局限性，同时保留其关键功能特征。在这里，我们回顾了体外肿瘤芯片微流控技术的最新进展，重点关注微血管化类器官模型的重建，为个性化癌症医学提供更好的平台。