This study was aimed at alleviating shortcomings in the treatment of periodontitis by preparation of a biopolymer membrane loaded with minocycline hydrochloride (MH) inserted into periodontal pockets to treat infections. Monomethoxy-poly (ethylene glycol)-poly (ε-caprolactone-co-L-lactide) (mPEG-PCLA) is a biocompatible and biodegradable amphiphilic block copolymer. It, therefore, has attracted considerable attention in drug delivery systems and periodontal treatment. We chose it as a membrane material for MH-drug loading. The MH-loaded membranes were prepared by the solvent casting technique with the content of 5, 8 and 10 wt.%, respectively. Fourier transform infrared spectra (FTIR) revealed no interaction between MH and polymer. The drug-loaded membrane surface morphology was investigated by scanning electron microscopy (SEM). In vitro release studies showed that the initial drug release exceeded 40% within 24 h, followed by a sustained release for up to 2 weeks, which would enable the therapeutic level to maintain over a longer time. The antibacterial activity studies in vitro demonstrated a positive effect on the periodontal pathogen. MH drug-loaded membranes have no adverse effect on the growth of periodontal ligament fibroblasts in the MTT test. The study suggests that mPEG-PCLA membranes containing MH are a potential antibacterial drug delivery system for local treatment of periodontitis.

这项研究的目的是通过制备一种生物聚合物膜来减轻牙周炎的不足，该生物聚合物膜中装有盐酸米诺环素（MH），该膜被插入牙周袋中以治疗感染。单甲氧基-聚（乙二醇）-聚（ε-己内酯-共-L-丙交酯）（mPEG-PCLA）是生物相容性和可生物降解的两亲嵌段共聚物。因此，它在药物输送系统和牙周治疗中引起了相当大的关注。我们选择它作为用于MH药物装载的膜材料。通过溶剂流延技术制备负载MH的膜，其含量分别为5、8和10重量％。傅立叶变换红外光谱（FTIR）显示MH与聚合物之间没有相互作用。通过扫描电子显微镜（SEM）研究载药的膜表面形态。体外释放研究表明，最初的药物释放在24小时内超过40％，然后持续释放长达2周，这将使治疗水平维持更长的时间。体外抗菌活性研究显示对牙周病原体有积极作用。在MTT试验中，MH载药膜对牙周膜成纤维细胞的生长没有不利影响。这项研究表明，含有MH的mPEG-PCLA膜是用于牙周炎局部治疗的潜在抗菌药物递送系统。体外抗菌活性研究显示对牙周病原体有积极作用。在MTT试验中，MH载药膜对牙周膜成纤维细胞的生长没有不利影响。这项研究表明，含有MH的mPEG-PCLA膜是用于牙周炎局部治疗的潜在抗菌药物递送系统。体外抗菌活性研究显示对牙周病原体有积极作用。在MTT试验中，MH载药膜对牙周膜成纤维细胞的生长没有不利影响。这项研究表明，含有MH的mPEG-PCLA膜是用于牙周炎局部治疗的潜在抗菌药物递送系统。