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Immuno-hormonal network in postmenopausal women: disturbance in breast cancer patients
Central European Journal of Immunology ( IF 1.3 ) Pub Date : 2021-03-18 , DOI: 10.5114/ceji.2021.104462 Andrew Glushkov 1 , Elena Polenok 1 , Lyudmila Gordeeva 1 , Stella Mun 1 , Mikhail Kostyanko 2 , Alexandr Antonov 3 , Natalia Verzhbitskaya 4 , Ilgiz Vafin 5
Central European Journal of Immunology ( IF 1.3 ) Pub Date : 2021-03-18 , DOI: 10.5114/ceji.2021.104462 Andrew Glushkov 1 , Elena Polenok 1 , Lyudmila Gordeeva 1 , Stella Mun 1 , Mikhail Kostyanko 2 , Alexandr Antonov 3 , Natalia Verzhbitskaya 4 , Ilgiz Vafin 5
Affiliation
Introduction
Antibodies to estradiol and progesterone (Es and Pg) modulated their blood serum concentration and biological effects in immunized animals. Antibodies to membrane steroid receptors acted as hormone agonists or antagonists in cell cultures.
Material and methods
Here we studied the levels of Es and Pg, idiotypic immunoglobulin (Ig) A1 and anti-idiotypic IgG2 specific to Es and Pg in the serum of postmenopausal women (82 healthy donors and 443 breast cancer patients).
Results
It was found that individual high ratios of Pg/Es (> 4), IgA-Pg1/IgA-Es1 (> 1) and IgG-Pg2/IgG-Es2 (> 1) were associated with low breast cancer risk (OR = 0.4-0.5). High ratios of IgA-Pg1/IgA-Es1 and IgG-Pg2/IgG-Es2 were associated with a high Pg/Es ratio in healthy women but not in breast cancer patients. The levels of idiotypic IgA to benzo[a]pyrene correlated significantly with IgA-Es1 and IgA-Pg1 levels in both compared groups. IgA-Pg1/IgA-Es1 ratio correlated with IgG-Pg2/IgG-Es2 only in healthy women but not in breast cancer patients.
Conclusions
The normal immune-hormonal balance supports the real adaptation of the organism to environmental carcinogens and inhibits the initiation and promotion of carcinogenesis. The disturbance between certain elements of this network (immune-hormonal disbalance) could stimulate carcinogenesis. Further studies of immune-hormonal interaction could be helpful for understanding the pathogenesis of other carcinogen-induced steroid-dependent diseases in humans.
中文翻译：
绝经后妇女的免疫激素网络：乳腺癌患者的紊乱
简介
雌二醇和孕酮（Es 和 Pg）抗体可调节免疫动物的血清浓度和生物学效应。膜类固醇受体的抗体在细胞培养物中充当激素激动剂或拮抗剂。
材料和方法
在这里，我们研究了绝经后妇女（82 名健康供体和 443 名乳腺癌患者）血清中 Es 和 Pg、独特型免疫球蛋白 (Ig) A1 和 Es 和 Pg 特异性抗独特型 IgG2 的水平。
结果
发现 Pg/Es (> 4)、IgA-Pg1/IgA-Es1 (> 1) 和 IgG-Pg2/IgG-Es2 (> 1) 的个体高比率与低乳腺癌风险相关 (OR = 0.4 -0.5)。IgA-Pg1/IgA-Es1 和 IgG-Pg2/IgG-Es2 的高比率与健康女性的高 Pg/Es 比率相关，但与乳腺癌患者无关。在两个比较组中，苯并[a]芘的独特型 IgA 水平与 IgA-Es1 和 IgA-Pg1 水平显着相关。IgA-Pg1/IgA-Es1 比率仅在健康女性中与 IgG-Pg2/IgG-Es2 相关，而在乳腺癌患者中不相关。
结论
正常的免疫激素平衡支持生物体对环境致癌物的真正适应，并抑制致癌作用的引发和促进。该网络的某些元素之间的干扰（免疫激素失衡）可能会刺激致癌作用。对免疫激素相互作用的进一步研究可能有助于了解人类其他致癌物诱导的类固醇依赖性疾病的发病机制。
更新日期：2021-04-18
Antibodies to estradiol and progesterone (Es and Pg) modulated their blood serum concentration and biological effects in immunized animals. Antibodies to membrane steroid receptors acted as hormone agonists or antagonists in cell cultures.
Material and methods
Here we studied the levels of Es and Pg, idiotypic immunoglobulin (Ig) A1 and anti-idiotypic IgG2 specific to Es and Pg in the serum of postmenopausal women (82 healthy donors and 443 breast cancer patients).
Results
It was found that individual high ratios of Pg/Es (> 4), IgA-Pg1/IgA-Es1 (> 1) and IgG-Pg2/IgG-Es2 (> 1) were associated with low breast cancer risk (OR = 0.4-0.5). High ratios of IgA-Pg1/IgA-Es1 and IgG-Pg2/IgG-Es2 were associated with a high Pg/Es ratio in healthy women but not in breast cancer patients. The levels of idiotypic IgA to benzo[a]pyrene correlated significantly with IgA-Es1 and IgA-Pg1 levels in both compared groups. IgA-Pg1/IgA-Es1 ratio correlated with IgG-Pg2/IgG-Es2 only in healthy women but not in breast cancer patients.
Conclusions
The normal immune-hormonal balance supports the real adaptation of the organism to environmental carcinogens and inhibits the initiation and promotion of carcinogenesis. The disturbance between certain elements of this network (immune-hormonal disbalance) could stimulate carcinogenesis. Further studies of immune-hormonal interaction could be helpful for understanding the pathogenesis of other carcinogen-induced steroid-dependent diseases in humans.
中文翻译：
绝经后妇女的免疫激素网络：乳腺癌患者的紊乱
简介
雌二醇和孕酮（Es 和 Pg）抗体可调节免疫动物的血清浓度和生物学效应。膜类固醇受体的抗体在细胞培养物中充当激素激动剂或拮抗剂。
材料和方法
在这里，我们研究了绝经后妇女（82 名健康供体和 443 名乳腺癌患者）血清中 Es 和 Pg、独特型免疫球蛋白 (Ig) A1 和 Es 和 Pg 特异性抗独特型 IgG2 的水平。
结果
发现 Pg/Es (> 4)、IgA-Pg1/IgA-Es1 (> 1) 和 IgG-Pg2/IgG-Es2 (> 1) 的个体高比率与低乳腺癌风险相关 (OR = 0.4 -0.5)。IgA-Pg1/IgA-Es1 和 IgG-Pg2/IgG-Es2 的高比率与健康女性的高 Pg/Es 比率相关，但与乳腺癌患者无关。在两个比较组中，苯并[a]芘的独特型 IgA 水平与 IgA-Es1 和 IgA-Pg1 水平显着相关。IgA-Pg1/IgA-Es1 比率仅在健康女性中与 IgG-Pg2/IgG-Es2 相关，而在乳腺癌患者中不相关。
结论
正常的免疫激素平衡支持生物体对环境致癌物的真正适应，并抑制致癌作用的引发和促进。该网络的某些元素之间的干扰（免疫激素失衡）可能会刺激致癌作用。对免疫激素相互作用的进一步研究可能有助于了解人类其他致癌物诱导的类固醇依赖性疾病的发病机制。
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