Most prospective studies of bone mineral density (BMD) in systemic lupus erythematosus (SLE) patients have been of relatively short duration, with a maximum of 6 years. To describe long-term changes in BMD in women with SLE and identify risk factors associated with BMD loss. We retrospectively evaluated 132 adult Mexican-Mestizo women with SLE who underwent dual X-ray absorptiometry (DXA). Demographic and clinical data were collected and BMD at the lumbar spine (L1–L4) and total hip were collected at baseline and during the follow up. At baseline, the mean age of participants was 43.4 ± 12.5 years, 50.8% had osteopenia and 11% osteoporosis. The median follow-up was 13 (IQR 10.2–14.0) years. During follow up, 79% of patients used glucocorticoid (GCT). The mean percentage of changes in BMD during follow up were: − 14.03 ± 11.25% (− 1.49%/year) at the lumbar spine, and − 15.77 ± 11.57% (− 1.78%/year) at the total hip, with significant changes (p < 0.001 for both comparisons). Multivariate analysis showed older age, GCT use at baseline, and transition to the menopause during the follow-up were significantly associated with greater reductions in BMD. This retrospective longitudinal study found significant BMD loss at the lumbar spine and hip. Older age, menopausal transition and GCT use were independently associated with BMD decline in women with SLE.

大多数系统性红斑狼疮 (SLE) 患者骨矿物质密度 (BMD) 的前瞻性研究持续时间相对较短，最长为 6 年。描述 SLE 女性 BMD 的长期变化，并确定与 BMD 损失相关的风险因素。我们回顾性评估了 132 名接受双 X 射线吸收测定法 (DXA) 的 SLE 成年墨西哥混血女性。收集人口统计学和临床​​数据，并在基线和随访期间收集腰椎（L1-L4）和全髋部的 BMD。在基线时，参与者的平均年龄为 43.4 ± 12.5 岁，50.8% 患有骨质减少症，11% 患有骨质疏松症。中位随访时间为 13 (IQR 10.2–14.0) 年。在随访期间，79% 的患者使用了糖皮质激素 (GCT)。随访期间 BMD 变化的平均百分比为：- 14.03 ± 11.25% (- 1. 两种比较的p < 0.001）。多变量分析显示年龄较大、基线时使用 GCT 以及随访期间过渡到更年期与 BMD 的更大降低显着相关。这项回顾性纵向研究发现腰椎和髋部的 BMD 显着减少。年龄较大、更年期过渡和 GCT 的使用与 SLE 女性的 BMD 下降独立相关。