Detailed analysis of cytodifferentiation and hormone production has classified pituitary neuroendocrine tumors (PitNETs) in a formal system that reflects the lineage differentiation of nontumorous adenohypophysial cells as well as subtypes of tumors that have predictive value. In addition, tumors composed of cells that lack terminal differentiation are well characterized. To comply with the proposal to create an overarching classification of neuroendocrine neoplasia, these tumors are now called PitNETs rather than adenomas. The next important step will be to relinquish the term “pituitary carcinoma” for metastatic PitNETs that remain well differentiated, and to alter the terminology used for tumors that are not terminally differentiated to reflect only their immature lineage. The existence of mixed neuroendocrine and non-neuroendocrine neoplasms (MiNENs) similar to those at other body sites is proven by mixed craniopharyngiomas with PitNETs. As with other NETs, these neoplasms should be reported with synoptic data that guide completeness of reporting. A formal system of grading should be created, but not only based on proliferation, as these tumors have shown the prognostic value of cytodifferentiation. A formal system of staging should also be devised to complement grade in the thorough and accurate diagnosis of tumors that arise from adenohypophysial cells.

对细胞分化和激素产生的详细分析已将垂体神经内分泌肿瘤 (PitNET) 分类为一个正式系统，该系统反映了非肿瘤性腺垂体细胞的谱系分化以及具有预测价值的肿瘤亚型。此外，由缺乏终末分化的细胞组成的肿瘤得到了很好的表征。为了符合创建神经内分泌瘤形成总体分类的提议，这些肿瘤现在被称为 PitNETs 而不是腺瘤。下一个重要的步骤将是对仍然分化良好的转移性 PitNET 放弃“垂体癌”一词，并改变用于未终末分化的肿瘤的术语以仅反映其未成熟的谱系。混合性颅咽管瘤与 PitNETs 证明存在与其他身体部位相似的混合神经内分泌和非神经内分泌肿瘤 (MiNENs)。与其他 NET 一样，这些肿瘤应与指导报告完整性的概要数据一起报告。应该建立一个正式的分级系统，但不仅仅是基于增殖，因为这些肿瘤已经显示出细胞分化的预后价值。还应设计一个正式的分期系统，以补充对腺垂体细胞引起的肿瘤进行彻底和准确诊断的分级。但不仅基于增殖，因为这些肿瘤已显示出细胞分化的预后价值。还应设计一个正式的分期系统，以补充对腺垂体细胞引起的肿瘤进行彻底和准确诊断的分级。但不仅基于增殖，因为这些肿瘤已显示出细胞分化的预后价值。还应设计一个正式的分期系统，以补充对腺垂体细胞引起的肿瘤进行彻底和准确诊断的分级。