当前位置：
X-MOL 学术
›
Ann. Thorac. Med.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Demographic and clinical patterns of severe asthma in the Middle East
Annals of Thoracic Medicine ( IF 2.1 ) Pub Date : 2021-04-01 , DOI: 10.4103/atm.atm_131_20 Mohamed Abuzakouk , OmarKhaled Hassan Attia Ghorab , Bassam Mahboub , Ashraf Alzaabi , MateenHaider Uzbeck , Mohsen Nasir , Zaid Zoumot , Deepa Grandon , YaserAbu El Sameed , Rajaie Namas , AliSaeed Wahla , Jeffrey Chapman , Khaled Saleh , Fulvio Salvo , GovindaSaicharan Bodi , Irfan Shafiq
BACKGROUND: Severe asthma is a major burden on health-economic resources; hence, knoing the epidemiology of these patients is important in planning and provision of asthma care. In addition, identifying and managing the comorbidities helps improve symptoms and reduce associated morbidity and mortality.
OBJECTIVES: Epidemiology of difficult asthma has not been ell studied in the Middle East, so in this study, e present the demographic and clinical characteristics of severe asthma in the United Arab Emirates (UAE).
METHODS: We retrospectively revieed the notes of severe asthma patients attending three tertiary care hospitals beteen May 2015 and December 2019. Data on baseline demographics, asthma characteristics, treatment, and comorbidities ere collected.
RESULTS: We revieed the notes of 458 patients (271 females and 187 males) that fulfilled the 2019 Global Initiative for Asthma guidelines for the diagnosis of severe asthma. The mean age as 47.7 (standard deviation 17.2) years. Males had significantly higher asthma control test scores (17.9 vs. 16, P = 0.01) and mean blood eosinophils (0.401 vs. 0.294, P <0.01) than females. The most common comorbidity observed as allergic rhinitis (52.2%) folloed by gastroesophageal reflux disease (27.1%). In total, 109 (23.8%) patients ere on biological therapies ith most patients being on omalizumab and dupilumab (29 and 18 patients, respectively). Most patients ere nonsmokers (97.2%), and majority ere of TH2-high phenotype (75.7%).
CONCLUSIONS: In this first report of severe asthma characteristics in the UAE, e found a pattern of female preponderance and most patients having a Th2-high phenotype. The findings are likely to help optimize asthma care in the region in the era of biologic therapies.
中文翻译：
中东地区严重哮喘的人口统计学和临床特征
背景：严重哮喘是健康，经济资源的主要负担。因此，了解这些患者的流行病学对计划和提供哮喘护理很重要。此外，识别和管理合并症有助于改善症状并降低相关的发病率和死亡率。
目的：中东尚未对难治性哮喘的流行病学进行研究，因此在本研究中，我们介绍了阿拉伯联合酋长国（UAE）的严重哮喘的人口统计学和临床特征。
方法：我们回顾性地回顾了2015年5月15日至2019年12月在三所三级医院就诊的重度哮喘患者的病历。收集了有关基线人口统计学，哮喘特征，治疗和合并症的数据。
结果：我们审查了458例患者的病历（271位女性和187位男性），这些患者符合2019年全球哮喘倡议针对严重哮喘的诊断指南。平均年龄为47.7岁（标准差为17.2）岁。男性的哮喘控制测试得分（17.9 vs. 16，P = 0.01）和平均血液嗜酸性粒细胞（0.401 vs. 0.294，P <0.01）显着高于女性。观察到最常见的合并症是变应性鼻炎（52.2％），随后是胃食管反流病（27.1％）。总共有109（23.8％）位患者接受了生物疗法，其中大多数患者接受了omalizumab和dupilumab的治疗（分别为29位和18位患者）。大多数患者为不吸烟者（97.2％），大部分为TH2高表型（75.7％）。
结论：在阿联酋首例严重哮喘特征报告中，e发现女性占优势，大多数患者具有Th2高表型。这些发现可能有助于在生物疗法时代优化该地区的哮喘护理。
更新日期：2021-04-18
Annals of Thoracic Medicine ( IF 2.1 ) Pub Date : 2021-04-01 , DOI: 10.4103/atm.atm_131_20 Mohamed Abuzakouk , OmarKhaled Hassan Attia Ghorab , Bassam Mahboub , Ashraf Alzaabi , MateenHaider Uzbeck , Mohsen Nasir , Zaid Zoumot , Deepa Grandon , YaserAbu El Sameed , Rajaie Namas , AliSaeed Wahla , Jeffrey Chapman , Khaled Saleh , Fulvio Salvo , GovindaSaicharan Bodi , Irfan Shafiq
BACKGROUND: Severe asthma is a major burden on health-economic resources; hence, knoing the epidemiology of these patients is important in planning and provision of asthma care. In addition, identifying and managing the comorbidities helps improve symptoms and reduce associated morbidity and mortality.
OBJECTIVES: Epidemiology of difficult asthma has not been ell studied in the Middle East, so in this study, e present the demographic and clinical characteristics of severe asthma in the United Arab Emirates (UAE).
METHODS: We retrospectively revieed the notes of severe asthma patients attending three tertiary care hospitals beteen May 2015 and December 2019. Data on baseline demographics, asthma characteristics, treatment, and comorbidities ere collected.
RESULTS: We revieed the notes of 458 patients (271 females and 187 males) that fulfilled the 2019 Global Initiative for Asthma guidelines for the diagnosis of severe asthma. The mean age as 47.7 (standard deviation 17.2) years. Males had significantly higher asthma control test scores (17.9 vs. 16, P = 0.01) and mean blood eosinophils (0.401 vs. 0.294, P <0.01) than females. The most common comorbidity observed as allergic rhinitis (52.2%) folloed by gastroesophageal reflux disease (27.1%). In total, 109 (23.8%) patients ere on biological therapies ith most patients being on omalizumab and dupilumab (29 and 18 patients, respectively). Most patients ere nonsmokers (97.2%), and majority ere of TH2-high phenotype (75.7%).
CONCLUSIONS: In this first report of severe asthma characteristics in the UAE, e found a pattern of female preponderance and most patients having a Th2-high phenotype. The findings are likely to help optimize asthma care in the region in the era of biologic therapies.
中文翻译：
中东地区严重哮喘的人口统计学和临床特征
背景：严重哮喘是健康，经济资源的主要负担。因此，了解这些患者的流行病学对计划和提供哮喘护理很重要。此外，识别和管理合并症有助于改善症状并降低相关的发病率和死亡率。
目的：中东尚未对难治性哮喘的流行病学进行研究，因此在本研究中，我们介绍了阿拉伯联合酋长国（UAE）的严重哮喘的人口统计学和临床特征。
方法：我们回顾性地回顾了2015年5月15日至2019年12月在三所三级医院就诊的重度哮喘患者的病历。收集了有关基线人口统计学，哮喘特征，治疗和合并症的数据。
结果：我们审查了458例患者的病历（271位女性和187位男性），这些患者符合2019年全球哮喘倡议针对严重哮喘的诊断指南。平均年龄为47.7岁（标准差为17.2）岁。男性的哮喘控制测试得分（17.9 vs. 16，P = 0.01）和平均血液嗜酸性粒细胞（0.401 vs. 0.294，P <0.01）显着高于女性。观察到最常见的合并症是变应性鼻炎（52.2％），随后是胃食管反流病（27.1％）。总共有109（23.8％）位患者接受了生物疗法，其中大多数患者接受了omalizumab和dupilumab的治疗（分别为29位和18位患者）。大多数患者为不吸烟者（97.2％），大部分为TH2高表型（75.7％）。
结论：在阿联酋首例严重哮喘特征报告中，e发现女性占优势，大多数患者具有Th2高表型。这些发现可能有助于在生物疗法时代优化该地区的哮喘护理。
京公网安备 11010802027423号