Aims:

To assess feasibility and acceptability of exercise in clinically referred adolescents with major depression.

Methods:

Outpatients12 to 17 years with mild to moderate persistent depression participated in a supervised, pulse monitored, 14-week aerobic exercise but without control group. Primary outcome was adherence and secondary was clinician-rated Quick Inventory of Depressive Symptomatology – Adolescent (QIDS-A₁₇-C), aerobic capacity, functioning, and well-being.

Results:

Twenty-one (66%) of 32 eligible adolescents with major depression with disease duration 2.4 (1.1–5.3) years and comorbid ADHD (71%) and anxiety disorders (62%) consented. Estimated maximum heart rate above 70% was achieved for mean 31.6 minutes, indicating that the intensity and duration of the exercise intervention was well received. Fourteen patients (67%) participated throughout the program and attended a median of 29 (81%, range 20–35) supporting satisfaction with the intervention by most patients. QIDS-A₁₇-C score decreased compared to baseline at 15 weeks (p < .001) and further at 1 year (p < .001). Aerobic capacity improved during the intervention but was not maintained, while functioning improved and after 1 year also well-being.

Conclusion:

This 14 week moderate to vigorous aerobic exercise intervention was feasible and well accepted by most adolescents with persistent depression and extensive comorbidities.

中文翻译：

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患有持续性重性抑郁症的青少年门诊患者的有氧运动：在临床参考样本中进行中度至剧烈团体运动的可行性和可接受性

目标：

评估临床转诊的重度抑郁症青少年锻炼的可行性和可接受性。

方法：

患有轻度至中度持续性抑郁症的 12 至 17 岁门诊患者参加了一项有监督的、脉搏监测的、为期 14 周的有氧运动，但没有对照组。主要结果是依从性，次要结果是临床医生评定的抑郁症状快速清单 - 青少年 (QIDS-A ₁₇ -C)、有氧能力、功能和幸福感。

结果：

32 名符合条件且病程为 2.4 (1.1-5.3) 年且患有 ADHD (71%) 和焦虑症 (62%) 的符合条件的青少年中的 21 名 (66%) 同意。平均 31.6 分钟达到了 70% 以上的估计最大心率，表明运动干预的强度和持续时间很受欢迎。14 名患者 (67%) 参与了整个计划，中位数为 29 (81%，范围 20-35) 的患者支持大多数患者对干预措施的满意度。QIDS-A ₁₇ -C 评分与基线相比在 15 周（p  < .001）和 1 年（p  < .001）进一步下降。有氧能力在干预期间有所改善，但并未维持，而功能有所改善，1 年后健康状况也有所改善。

结论：

这种为期 14 周的中度到剧烈有氧运动干预是可行的，并且被大多数患有持续性抑郁症和广泛合并症的青少年广泛接受。