A new zinc complex [Zn(L1)Cl₂]₂‧CH₃OH‧2H₂O (complex 1), where L1 stands for 2,6-Bis{[(4-ethylphenyl)imino]ethyl}pyridine (L1) has been synthesized and characterized. The crystal structure of L1 and complex 1 have been determined by single-crystal X-ray diffraction. Both compounds crystallize in the monoclinic P2₁/c space group. For the ligand L1, the crystal parameters are a = 16.7487(7) Å, b = 5.8177(3) Å, c = 21.8427(10) Å, β = 104.1350(10)° and Z = 4. For complex 1, the crystal parameters are a = 8.0216(14) Å, b = 13.433(2) Å, c = 24.640(4) Å, β = 90.223(3)° and Z = 2. In the crystal structure of complex 1, L1 acts as a tridentate ligand and coordinated with Zn1 with three nitrogen atoms. Together with two chlorine atoms, Zn1 atom is five-coordinated in a trigonal bipyramidal geometry. Hydrogen bonds play great role in the crystal structure of complex 1 and form a two-dimensional network. Furthermore, the DNA-binding property of complex 1 with fish sperm DNA (FS-DNA) has been investigated by electronic absorption titration. The result suggests that complex 1 might interact with FS-DNA via groove binding mode.

Graphical abstract

The single crystals of 2,6-Bis{[(4-ethylphenyl)imino]ethyl}pyridine (L1) and it’s Zinc(II) complex [Zn(L1)Cl₂]‧CH₃OH‧H₂O (1) were determined. In the crystal structure of complex 1, Zn1 atom is five-coordinated in a trigonal bipyramidal geometry. A two-dimensional network is formed by hydrogen bonds. DNA-binding study indicated that complex 1 interact with FS-DNA via groove binding mode.

中文翻译：

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基于2,6-双（亚氨基）吡啶基配体的新型锌（II）配合物的合成，晶体结构和DNA结合研究

一种新的锌配合物[锌（L1）氯₂ ] ₂ ‧CH ₃ OH‧2H ₂ O（复杂1），其中L1代表2,6-双{[（4-乙基苯基）亚氨基]乙基}吡啶（L1）已经合成和表征。L1和配合物1的晶体结构已经通过单晶X射线衍射确定。两种化合物均在单斜P2 ₁ / c空间群中结晶。对配体L1时，晶体参数是一个 = 16.7487（7），b  = 5.8177（3）埃，c ^  = 21.8427（10）A，β  = 104.1350（10）度和Ž  = 4。对于复杂1，该晶体参数是a  = 8.0216（14）Å，b  = 13.433（2）Å，c  = 24.640（4）Å，β  = 90.223（3）°且Z  =2。在配合物1的晶体结构中，L1充当三齿配体并与带有三个氮原子的Zn1配位。Zn1原子与两个氯原子一起在三角双锥几何结构中五配位。氢键在配合物1的晶体结构中起重要作用，并形成二维网络。此外，已经通过电子吸收滴定研究了配合物1与鱼精DNA（FS-DNA）的DNA结合特性。结果表明，复数1 可能通过凹槽结合模式与FS-DNA相互作用。

图形概要

2,6-双{[（（4-乙基苯基）亚氨基]乙基}吡啶（L1）及其锌（II）络合物[Zn（L1）Cl ₂ ]·CH ₃ OH·H ₂ O（1）的单晶。被确定。在配合物1的晶体结构中，Zn1原子在三角双锥几何结构中是五配位的。氢键形成二维网络。DNA结合研究表明复合物1通过凹槽结合模式与FS-DNA相互作用。