Abstract

Spray-drying is an inherently continuous and well-established industrial drying process. It can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both an economic and health benefit. In this review, we cover a systematic assessment and discuss the spray-drying of diverse protein pharmaceuticals and excipients included therein, solvent systems applicable to these formulations, equipment used and, respective process parameters. Further, key quality aspects of spray-dried protein solids are discussed. Based on the overall trends, we present a concise perspective into the future of protein pharmaceuticals spray-drying.

中文翻译：

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蛋白质药物喷雾干燥研究进展：配方及工艺属性趋势文献分析

摘要

喷雾干燥是一种固有的连续和完善的工业干燥过程。它可以加速生物制药和疫苗产品的制造，从而带来经济和健康效益。在这篇综述中，我们涵盖了系统评估并讨论了其中包含的各种蛋白质药物和赋形剂的喷雾干燥、适用于这些制剂的溶剂系统、使用的设备以及各自的工艺参数。此外，还讨论了喷雾干燥蛋白质固体的关键质量方面。基于整体趋势，我们对蛋白质药物喷雾干燥的未来进行了简要的展望。