A compact and label-free biosensor based on coreless-fiber-coupled microcavity is proposed and experimentally demonstrated for bovine serum albumin (BSA) detection. The microcavity is fabricated in a coreless fiber by on-line fiber cutting-welding micromachining. Experimental results show that the BSA samples with different concentration and refractive index ranging from 1.3344 to 1.3349 are clearly discriminated by spectral characteristics of the coreless-fiber-coupled microcavity, with a sensitivity of 1.602 nm/(mg/ml). The device presents superiorities such as miniature size, standardized production control, reliable quality, and cost effective, which makes it a good candidate for the detection of low-concentration micro-samples analytes in the fields of life sciences, biological engineering, and biopharmaceutical industry.

中文翻译：

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基于无芯光纤耦合微腔的无标记生物传感器用于蛋白质检测


提出了一种基于无芯光纤耦合微腔的紧凑型无标记生物传感器，并通过实验证明可用于牛血清白蛋白（BSA）检测。通过在线光纤切割焊接微机械加工在无芯光纤中制造微腔。实验结果表明，无芯光纤耦合微腔的光谱特性可以清晰地区分不同浓度、折射率在1.3344~1.3349范围内的BSA样品，灵敏度为1.602 nm/(mg/ml)。该装置具有体积小、生产控制标准化、质量可靠、成本低廉等优点，适合生命科学、生物工程、生物制药等领域低浓度微量样品分析物的检测。 。