In this study, manganese tellurite (MnTeO₃) nanoparticles are developed as theranostic agents for magnetic resonance imaging (MRI)-guided photothermal therapy of tumor. MnTeO₃ nanoparticles are synthesized via a simple one-step method. The as-synthesized MnTeO₃ nanoparticles with uniform size show good biocompatibility. In particular, MnTeO₃ nanoparticles exhibit a high photothermal conversion efficiency (η = 26.3%), which is higher than that of gold nanorods. Moreover, MnTeO₃ nanoparticles also have high MRI performance. The longitudinal relaxivity (r₁) value of MnTeO₃ nanoparticles is determined to be 8.08 ± 0.2 mm⁻¹ s⁻¹, which is higher than that of clinically approved T₁-contrast agents Gd-DTPA (4.49 ± 0.1 mm⁻¹ s⁻¹). The subsequent MnTeO₃ nanoparticles-mediated photothermal therapy displays a highly efficient ablation of tumor cells both in vitro and in vivo with negligible toxicity. It is demonstrated that MnTeO₃ nanoparticles can serve as promising theranostic agents with great potentials for MRI-guided photothermal therapy.

中文翻译：

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磁共振成像引导光热疗法轻松合成锰碲石纳米粒子

在这项研究中，亚碲酸锰（MnTeO ₃）纳米颗粒被开发为用于磁共振成像（MRI）引导的肿瘤光热疗法的治疗剂。MnTeO ₃纳米颗粒是通过简单的一步法合成的。刚合成的尺寸均匀的MnTeO ₃纳米颗粒具有良好的生物相容性。尤其是，MnTeO ₃纳米颗粒表现出高的光热转化效率（η= 26.3％），高于金纳米棒的光热转化效率。而且，MnTeO ₃纳米颗粒也具有较高的MRI性能。MnTeO ₃纳米颗粒的纵向弛豫度（r ₁）值确定为8.08±0.2 m m ^-1s ^-1，高于临床批准的T ₁造影剂Gd-DTPA（4.49±0.1 m m ^-1 s ^-1）。随后的MnTeO ₃纳米粒子介导的光热疗法在体内和体外均显示出高效的肿瘤细胞消融，且毒性可忽略不计。结果表明，MnTeO ₃纳米粒子可以作为有前景的治疗药物，在MRI引导的光热疗法中具有巨大的潜力。