Could chemical exposure and bioconcentration in fish be affected by slow binding kinetics in blood?,Environmental Science: Processes & Impacts

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Could chemical exposure and bioconcentration in fish be affected by slow binding kinetics in blood?
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2021-4-8 , DOI: 10.1039/d1em00056j
Sophia Krause _{1,

2,

3,

4} , Kai-Uwe Goss _{1,

2,

3,

4,

5}

Affiliation

The possible implications of slow binding kinetics on respiratory uptake, bioconcentration and exposure of chemicals were evaluated in the present study. Most physiological and chemical information needed for such an evaluation is already known from the literature or can be estimated. However, data for binding kinetics of chemicals in fish plasma have not been reported in the literature yet. In the first part of this study, we therefore experimentally investigated the plasma binding kinetics for ten chemicals, including pollutants like polycyclic aromatic hydrocarbons and a pesticide. The determined desorption rate constants were in the range of 0.4 s⁻¹ to 0.1 s⁻¹. In the second part of this study, we present a comparative modeling analysis of generic predictions with binding kinetics of different velocities. For doing so, a model that explicitly represents binding kinetics in blood was developed and applied for different hypothetical scenarios. The evaluation showed that slow sorption kinetics only limits respiratory uptake and thus influences the levels of bioaccumulation for extreme and, by that, rather unlikely parameter combinations (i.e. for strongly sorbing chemicals with very slow binding kinetics). It can therefore be assumed that limitations on respiratory uptake due to slow binding kinetics in blood are rather unlikely for most chemicals.

中文翻译：

血液中缓慢的结合动力学会影响鱼类的化学暴露和生物富集吗？

在本研究中评估了缓慢的结合动力学对呼吸吸收，生物浓缩和化学物质暴露的可能影响。这种评估所需的大多数生理和化学信息已从文献中获悉或可以估计。但是，有关鱼血浆中化学物质结合动力学的数据尚未在文献中报道。因此，在本研究的第一部分中，我们通过实验研究了十种化学物质的血浆结合动力学，其中包括多环芳烃和农药等污染物。所确定的解吸速率常数在0.4 s ^-1至0.1 s ^-1的范围内。在本研究的第二部分中，我们对具有不同速度的结合动力学的一般预测进行了比较建模分析。为此，开发了一个明确代表血液中结合动力学的模型，并将其应用于不同的假设场景。评价结果表明缓慢的吸附动力学只限呼吸道吸收，从而影响生物累积极端的水平，并通过，而不太可能的参数组合（即用于吸附强烈的化学物质非常缓慢的结合动力学）。因此可以假设，对于大多数化学药品而言，由于血液中缓慢的结合动力学而导致的呼吸吸收限制不太可能发生。

更新日期：2021-04-16

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